This test measures pregnanediol, a metabolite of progesterone, in urine. It serves several important purposes in reproductive health assessment and management.
Fertility evaluation: Assists in diagnosing issues related to difficulty conceiving or maintaining pregnancy.
Pregnancy monitoring: Used to monitor "high-risk" pregnancies.
Ovulation confirmation: Helps determine if and when ovulation has occurred.
Luteal phase assessment: Evaluates the adequacy of progesterone production after ovulation.
Progesterone therapy monitoring: Used to track the effectiveness of progesterone supplementation.
Pregnanediol levels reflect progesterone production by the ovaries and placenta. Progesterone plays a crucial role in:
Preparing the endometrium for potential implantation of a fertilized egg.
Maintaining early pregnancy.
Supporting fetal development throughout pregnancy.
Follicular phase: Low levels
Ovulation: Rapid increase
Luteal phase: Significantly elevated levels
Pregnancy: Continued elevation due to placental production
Ovulation tracking: The rapid rise in pregnanediol after ovulation makes this test useful for pinpointing ovulation timing.
Pregnancy monitoring: Regular testing can assess placental health in high-risk pregnancies or women with a history of pregnancy complications.
Luteal phase deficiency: Helps diagnose and monitor treatment for inadequate progesterone production during the luteal phase.
While urinary pregnanediol assays are common, they may be supplemented or replaced by plasma progesterone tests, which offer quicker results and greater accuracy.
Luteal (premenopausal): 200 - 740
Postmenopausal: 15 - 50
Follicular: 25 - 100
Ovulatory: 25 - 100
With oral progesterone (100mg): 580 - 3000
Male: 20 - 130
Note: For premenopausal women, this test is typically performed during the luteal phase (days 19-22 of a 28-day cycle).
The pregnanediol test is a valuable tool in reproductive endocrinology, offering insights into ovarian function, ovulation, and early pregnancy health. It's particularly useful in fertility assessments and monitoring high-risk pregnancies, though it may be complemented or replaced by serum progesterone tests in some clinical settings.
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Generally high progesterone levels indicate you are high for the luteal phase.
High progesterone metabolites can occur with progesterone or pregnenolone supplementation.
It can also occur with stress as the adrenals release more progesterone during stress, although ovarian production will exceed adrenal production with ovulation.
High progesterone is also seen in PCOS when ovulation occurs because of excessive luteinizing hormone secretion. Some women may naturally make high levels of progesterone and, if symptom free, it is usually not concerning. Symptoms of high progesterone may include bloating, fatigue and food cravings, especially high calorie foods.
Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
Low or low-normal levels of pregnanediol indicate suboptimal progesterone production. Pregnanediol is a metabolite of progesterone, and its measurement in urine can provide valuable insights into progesterone levels and ovarian function.
Insufficient progesterone commonly results in an increase in symptoms during the luteal phase of the menstrual cycle. These symptoms may include:
Sleep disturbances
Anxiety and mood changes
Increased stress sensitivity
Irregular menstrual cycles
Difficulty conceiving
Headaches or migraines
Breast tenderness
In perimenopausal years, progesterone levels tend to decline more rapidly than estrogen levels, resulting in a state of relative estrogen dominance. This hormonal imbalance can exacerbate perimenopausal symptoms.
Anovulation: Without ovulation, a corpus luteum does not develop, leading to decreased progesterone production.
Stress: Chronic stress can interfere with the hypothalamic-pituitary-ovarian axis, potentially reducing progesterone production.
Obesity: Excess body fat can lead to hormonal imbalances, including lower progesterone levels.
Poor diet: Nutritional deficiencies can impact hormone production and metabolism.
Ovarian hypofunction: Conditions that impair ovarian function can lead to lower progesterone and pregnanediol levels.
Pregnancy complications: In pregnant women, decreased pregnanediol may indicate threatened placental viability, as the placenta is a major source of progesterone during pregnancy.
Ovarian neoplasms: In rare cases, ovarian cancers can destroy functional ovarian tissue, potentially decreasing progesterone levels.
In postmenopausal women, pregnanediol levels are expected to be significantly lower than in premenopausal women with optimal luteal function, due to the natural decline in ovarian hormone production.
Pregnanediol measurements can be useful for:
Confirming ovulation
Assessing luteal phase adequacy
Monitoring the effectiveness of progesterone therapy
Lifestyle modifications:
Stress reduction techniques (e.g., meditation, yoga)
Regular exercise
Balanced diet rich in nutrients supporting hormone production
Botanical supports: Certain herbs may help support progesterone production or mimic its effects, but should be used under professional guidance.
Supplemental progesterone: Bioidentical progesterone can be prescribed to address symptoms of low progesterone, particularly in perimenopausal women.
Addressing underlying causes: Treatment of conditions like PCOS or thyroid disorders that may be impacting progesterone levels.
Regular monitoring: Ongoing assessment of hormone levels and symptoms to adjust treatment as needed.
It's important to consult with a healthcare provider for proper diagnosis and treatment of hormonal imbalances, as individual needs can vary significantly. They can provide personalized advice and monitor your progress to ensure optimal hormonal health.
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Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
Healthmatters is a highly-personalized health dashboard.
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We’ve crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
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