MHAs are metabolites of xylene (dimethylbenzenes). Xylenes are widely used as solvents in products including paints, detergents, pesticides, fuel, perfumes, and exhaust fumes. The main effect of inhaling xylene vapor is depression of the central nervous system (CNS), with symptoms such as headache, dizziness, nausea, and vomiting.
Long-term exposure may lead to irritability, depression, insomnia, agitation, extreme tiredness, tremors, hearing loss, impaired concentration, and short-term memory loss. A condition called chronic solvent-induced encephalopathy, commonly known as "organic solvent syndrome" has been associated with xylene exposure.
Understand and improve your laboratory results with our health dashboard.
Upload your lab reports and get your interpretation today.
Our technology helps to understand, combine, track, organize, and act on your medical lab test results.
Avoid/reduce exposure to these substances.
Xylenes (dimethylbenzenes) are found not only in common products such as paints, lacquers, pesticides, cleaning fluids, fuel and exhaust fumes, but also in perfumes and insect repellents. Xylenes are oxidized in the liver and bound to glycine before eliminated in urine. High exposures to xylene create an increase in oxidative stress, causing symptoms such as nausea, vomiting, dizziness, central nervous system depression, and death. Occupational exposure is often found in pathology laboratories where xylene is used for tissue processing.
---------------------
Methylhippuric acid (2,-3,4-MHA) is the result of exposure to the solvent xylene that is widespread in the environment. Xylene is found in paints, lacquers, cleaning agents, pesticides, and gasoline. It is also used in the pathology laboratory for tissue processing.
High exposure to xylene may cause nausea, vomiting, dizziness, incoordination, central nervous system depression, and even death. An exposure to 100 ppm xylene in the air resulted in a urine value of 3140 µg/g creatinine for methylhippuric acid.
Rats given xylene experienced a significant decrease in locomotor activity, deficits in learning ability and memory loss. These xylene -induced behavioral changes were associated with a decrease in beta-endorphins.
Possible treatment options:
Treatment begins with removing all potential sources of exposure. Elimination of xylene can be accelerated by sauna treatment, the Hubbard detoxification protocol employing niacin supplementation, supplementation with glycine to encourage metabolism of xylene to methylhippuric acid in the liver, or by glutathione (reduced) supplementation (oral, intravenous, transdermal, or precursors such as N-acetyl cysteine [NAC]).
Interpret Your Lab Results
Upload your lab report, and we'll interpret and provide you with recommendations today.
Get Started
Monthly plan
Annual plan
Own it for life
Our exclusive data entry service is a convenient way to get your results into your private dashboard. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. We support all sorts of files, whether PDFs, JPGs, or Excel. This service is excellent whether you have a lot of reports to upload or are too busy to do the data entry yourself.
We strive to make the data entry process easy for you. Whether by offering dozens of templates to choose from that pre-populate the most popular laboratory panels or by giving you instant feedback on the entered values. Our data entry forms are an easy, fast, and convenient way to enter the reports yourself. There is no limit on how many lab reports you can upload.
$15 /month
billed every month
Most popular
Data entry included
$79 /year
$6.60/month billed annually
Data entry included
$250 /once
own it for life
Are You a Health Professional?
Get started with our professional plan
Welcome to Healthmatters Pro.
Save time on interpreting lab results with the largest database of biomarkers online. In-depth research on any test at your fingertips, all stored and tracked in one place. Learn more
Pro Monthly Plus
for health professionals
$75 per month
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
