MEHP is a metabolite of Bis(2-ethylhexyl)phthalate (DEHP) which belongs to the most common environmental toxin phthalates.
Phthalates, often known as plasticizers, are a group of chemicals used to make plastics more flexible and harder to break. They are widely used in:
- cosmetics,
- adhesives,
- detergents,
- lubricating oils,
- automotive plastics,
- and plastic clothes.
People are exposed to phthalates by eating or drinking contaminated foods, but also by breathing in air that contains phthalate vapors or dusts. Inhaling phthalates can irritate the nose and throat, causing coughing and wheezing, headache, dizziness, and nausea. DEHP measured from the blood of pregnant women has been significantly associated with decreased penis width, shorter anogenital distance, and the incomplete descent of testes of their newborn sons, replicating effects identified in animals. Phthalates have been classified as endocrine disruptors which may cause reproductive damage, depressed leukocyte function, and even cancer. Phthalate exposure has also been associated with diabetes and insulin resistance, breast cancer, obesity, metabolic disorders, and immune disorders. Phthalate exposure and adverse child neurodevelopment, including the development of ADHD and autistic behaviors and lower cognitive and motor development, has also been reported.
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MEHP is a metabolite of Bis(2-ethylhexyl)phthalate (DEHP) which belongs to the most common environmental toxin phthalates.
Phthalates, often known as plasticizers, are a group of chemicals used to make plastics more flexible and harder to break. They are widely used in:
- cosmetics,
- adhesives,
- detergents,
- lubricating oils,
- automotive plastics,
- and plastic clothes.
People are exposed to phthalates by eating or drinking contaminated foods, but also by breathing in air that contains phthalate vapors or dusts. Inhaling phthalates can irritate the nose and throat, causing coughing and wheezing, headache, dizziness, and nausea. DEHP measured from the blood of pregnant women has been significantly associated with decreased penis width, shorter anogenital distance, and the incomplete descent of testes of their newborn sons, replicating effects identified in animals. Phthalates have been classified as endocrine disruptors which may cause reproductive damage, depressed leukocyte function, and even cancer. Phthalate exposure has also been associated with diabetes and insulin resistance, breast cancer, obesity, metabolic disorders, and immune disorders. Phthalate exposure and adverse child neurodevelopment, including the development of ADHD and autistic behaviors and lower cognitive and motor development, has also been reported.
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