Function:

Thyroglobulin (Tg) is a glycoprotein formed by two identical subunits. Tg is synthesized in thyrocytes and released into thyroid follicles where it is most abundant. Tg plays the main role in coupling of iodinized tyrosine residues to form hormones, triiodothyronine (T3) and thyroxine (T4), through its specific sites. In order to release these hormones, the thyroid gland has to reabsorb the Tg droplets from the follicular lumen into folicular cells. A small fraction of Tg (around 100 mcg) is released from thyroid on a daily basis.

Antibodies Appear:

Autoimmune Thyroid Disease [1, 2, 3]

Hashimoto’s Thyroiditis [1, 2, 3]

Graves’ Disease [1, 2]

Known Cross-Reactions:

Thyroid peroxidase, [4] heat shock protein, [5] Latex hevein [6]

Function:

Thyroid peroxidase (TPO) is an enzyme expressed mainly in the thyroid that frees iodine for its addition onto thyroglobulin tyrosine residues for the production of thyroxine (T4) or triiodothyronine (T3), thyroid hormones.

Some TPO antibodies may lyse thyroid cells or inhibit TPO enzyme activity, in vitro [2, 7] but in general it is considered an antibody response to thyroid damage inflicted by T-Cells.

Antibodies Appear:

Autoimmune Thyroid Disease [1, 3, 5, 6]

Graves’ Disease [3]

Hashimoto’s Thyroiditis [2]

Vitiligo [3, 4]

Known Cross-Reactions:

Thyroglobulin, [9]

Gliadin, [10]

Helicobacter pylori, [11]

heat shock protein [12]

Thyroid peroxidase (TPO) is an enzyme that is critical for to thyroid hormone synthesis in the thyroid gland. Thyroid peroxidase (TPO) antibodies bind to and block the action of TPO, resulting in decreases in thyroid hormone levels. The presence of TPO antibodies in the blood is abnormal and usually indicates thyroid disease. The thyroid peroxidase (TPO) antibodies test is usually ordered after thyroid abnormalities have been detected with some other type of testing, such as TSH and free T4. It is usually ordered with thyroglobulin antibody testing.

Function:

Thyroid peroxidase (TPO) is an enzyme expressed mainly in the thyroid that frees iodine for its addition onto thyroglobulin tyrosine residues for the production of thyroxine (T4) or triiodothyronine (T3), thyroid hormones. Some TPO antibodies may lyse thyroid cells or inhibit TPO enzyme activity, in vitro [2, 7] but in general it is considered an antibody response to thyroid damage inflicted by T-Cells.

Antibodies Appear:

Autoimmune Thyroid Disease [1, 3, 5, 6]

Graves’ Disease (an immune system disorder that results in the overproduction of thyroid hormones) [3]

Hashimoto’s Thyroiditis (can cause your thyroid to not make enough thyroid hormone.)[2]

Vitiligo [a chronic (long-lasting) autoimmune disorder that causes patches of skin to lose pigment or color.] [3, 4]

Known Cross-Reactions:

- Thyroglobulin, [9]

- gliadin, [10]

- Helicobacter pylori, [11]

- heat shock protein [12]

The measurement of thyroid stimulating autoantibodies, in conjunction with other clinical and laboratory findings, is used as an aid in the diagnosis of patients suspected of having Graves' disease.

Thyroid stimulating hormone (TSH) is one of the most important hormones currently used to diagnose thyroid abnormalities. This glycoprotein is secreted by the pituitary and stimulates release of thyroxine (T4) and triiodothyronine (T3) from the thyroid gland.

TSH release from the pituitary is controlled by thyrotropin releasing hormone (TRH) stimulation and negative feedback from free T3 and free T4.

The Thyrotropin Receptor Ab test detects the autoantibody that's associated with Graves' disease. An antibody is a specialized protein made by your immune system. Antibodies are custom made to kill pathogens in your body, such as viruses or bacteria.

Thyrotropin is also called thyroid-stimulating hormone, or TSH. TSH binds to receptors on the thyroid gland to tell it to produce thyroid hormone. The thyrotropin receptor antibody mimics TSH, so when it's present, it directs the thyroid to keep releasing hormone when your body doesn't need it. That results in high levels of thyroid hormones, which is what causes symptoms. If the thyrotropin receptor antibody is present, it's an indicator of Graves' disease.

Thyroid-binding globulin (TBG) is produced in the liver and is the primary circulating (transport) protein that binds thyroid hormones3,5,3’-triiodothyronine (T3) and thyroxine (T4) and carries them in the bloodstream.

Thyroid-binding globulin (TBG) is produced in the liver and is the primary circulating (transport) protein that binds thyroid hormones3,5,3’-triiodothyronine (T3) and thyroxine (T4) and carries them in the bloodstream.

What is Tickborne Encephalitis Virus – IgG?

Tickborne Encephalitis Virus (TBEV) is a virus that causes tickborne encephalitis (TBE)—a serious infection affecting the brain and central nervous system. TBEV is transmitted through the bite of infected Ixodes ticks, and is most commonly found in parts of Central and Eastern Europe, Russia, and Northern and Eastern Asia.

The IgG antibody test for TBEV detects long-term immune response to the virus. IgG antibodies typically develop several weeks after infection or vaccination and can remain in the bloodstream for months or years, indicating past exposure, recovery from infection, or prior vaccination.

What is Tickborne Encephalitis Virus – IgM?

Tickborne Encephalitis Virus (TBEV) is a virus that causes tickborne encephalitis (TBE), a potentially serious illness affecting the brain and central nervous system. TBEV is spread through the bite of infected Ixodes ticks and is most common in parts of Central and Eastern Europe, Russia, and northern and eastern Asia.

The IgM antibody test detects the body’s initial immune response to the virus. IgM antibodies are the first type produced by the immune system after exposure to an infection—usually appearing within 1 to 2 weeks. Because of this, an elevated IgM level typically indicates a recent or active infection with TBEV.

What Does a Medium Result Mean?

A medium IgM result indicates a moderate level of early antibodies, which may reflect:

• An early stage of infection, where the immune response is still increasing

• A declining IgM response, as the body transitions to producing longer-term IgG antibodies

• A borderline or nonspecific response, which may require confirmation with additional testing

Medium results should be interpreted alongside clinical symptoms, travel or exposure history, and other tests such as TBEV IgG or PCR.

Tiglylglycine (TG) is an organic acid and a biomarker of mitochondrial function. It is produced when the body metabolizes the amino acid isoleucine. In healthy individuals, mitochondria—the “power plants” of our cells—process it efficiently, keeping TG levels very low.

When TG levels are elevated in urine, it may indicate mitochondrial dysfunction or, in rare cases, an inherited metabolic disorder. For this reason, TG is often included in organic acids tests as part of evaluating cellular energy health.

A moderate level of Tiglylglycine (TG) in urine suggests your mitochondria—the parts of your cells that produce energy—may not be working at full efficiency. This level is above the expected range but not as high as those seen in severe mitochondrial dysfunction or rare genetic disorders. Moderate results often reflect stress on the mitochondria from triggers such as toxin exposure, inflammation, chronic infection, or nutritional deficiencies. While not immediately dangerous, this finding means your body may be struggling with energy metabolism, which can contribute to symptoms like fatigue, muscle weakness, or brain fog. Supporting mitochondrial health through better nutrition, detoxification strategies, and lifestyle changes can help bring levels back toward the optimal range.

Tiglylglycine is a marker for mitochondrial dysfunction. Mutations of mitochondria DNA may result from exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies.

SOURCES:

Found in manufacturing, food, packaging, solder, bronzing, dyeing textiles, plastics, PVC pipes, fungicides, toothpaste, perfume, soap, food additives, electronic, cigarette aerosol, and dyes. Naturally present and rocks and nearby air, water, and soil. Seafood is the primary route of human exposure to tin compounds. Tin is found in both organic and inorganic forms. Inorganic tin is generally regarded as safe by the FDA as a food additive for human consumption.

Nutrient interactions:

Tin disturbs copper, zinc, and iron metabolism.