Estradiol is an estrogen and the primary female sex hormone. There are three natural estrogens in females which include Estrone (E1), Estradiol (E2), and Estriol (E3). Estradiol is the most active of all three estrogens. Estradiol is important in the regulation of the menstrual female reproductive cycles. It is released from the ovaries and adrenal glands and plays a major part in the development of female reproductive tissues including the breasts, uterus, fallopian tubes, and vagina throughout the stages of life. It also has an effect on other tissues such as bone, fat, skin, liver and the brain. It is important to compare the relationship between estradiol and progesterone when evaluating menopausal symptoms which may include hot flashes, mood disorders, and aging skin.
|Pre-Menopause||-||Female||0.60 - 4.50||pg/mL|
|Post-Menopause||-||Female||0.50 - 3.20||pg/mL|
|Therapeutic||-||Female||1 - 6||pg/mL|
|0 - 12||Male||< 1.80||pg/mL|
|13 - 99||Male||< 2.50||pg/mL|
Low estradiol levels may suggest menopause, ovarian failure (premature menopause which occurs when the ovaries stop functioning before the age of 40), depleted estrogen production (caused by low body fat), hypogonadism (occurs when the ovaries or testes don’t produce enough hormone), or osteoporosis.
High estradiol levels could be signs of early puberty, gynecomastia (when men develop breasts), tumors in the ovaries or testes, hyperthyroidism (overactive thyroid gland), or cirrhosis (scarring of the liver). Specifically in males, high levels of estradiol are associated with abdominal fat, enlargement of the prostate and cardiovascular risk.
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