Estradiol (E2)
Optimal Result:
0.6 - 4.5 pg/mL.
Estradiol is an estrogen and the primary female sex hormone. There are three natural estrogens in females which include Estrone (E1), Estradiol (E2), and Estriol (E3). Estradiol is the most active of all three estrogens. Estradiol is important in the regulation of the menstrual female reproductive cycles. It is released from the ovaries and adrenal glands and plays a major part in the development of female reproductive tissues including the breasts, uterus, fallopian tubes, and vagina throughout the stages of life. It also has an effect on other tissues such as bone, fat, skin, liver and the brain. It is important to compare the relationship between estradiol and progesterone when evaluating menopausal symptoms which may include hot flashes, mood disorders, and aging skin.
| Reference Range(s) | |||||
| Condition | Age | Sex | Range | Units | |
| Pre-Pubesecent | - | Female | < 1.80 | pg/mL | |
| Pre-Menopause | - | Female | 0.60 - 4.50 | pg/mL | |
| Post-Menopause | - | Female | 0.50 - 3.20 | pg/mL | |
| Therapeutic | - | Female | 1 - 6 | pg/mL | |
| 0 - 12 | Male | < 1.80 | pg/mL | ||
| 13 - 99 | Male | < 2.50 | pg/mL | ||
Lab Results Explained and Tracked
What does it mean if your Estradiol (E2) result is too high?
High estradiol levels could be signs of early puberty, gynecomastia (when men develop breasts), tumors in the ovaries or testes, hyperthyroidism (overactive thyroid gland), or cirrhosis (scarring of the liver). Specifically in males, high levels of estradiol are associated with abdominal fat, enlargement of the prostate and cardiovascular risk.
Symptoms:
→ Mood swings,
→ Anxiety
→ Water retention
→ Weight gain in the hips
→ Nervous, Irritability
→ Thyroid deficiency
Possible causes:
→ Ovarian dysfunction
→ Excessive production of androgens
→ Increased aromatization
→ Exogenous supplementation
→ Decreased SHBG levels
Treatment considerations:
→ Assess and support 2+16 hydroxylation pathways
→ Test and treat liver detoxification
→ Consider weight loss if increased BMI
→ Decreased exposure to xenoestrogens
→ Nutritional interventions (natural aromatase inhibitors, soy foods)
→ Exercise and weight bearing programs
→ Natural progesterone supplementation
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What does it mean if your Estradiol (E2) result is too low?
Low estradiol levels may suggest menopause, ovarian failure (premature menopause which occurs when the ovaries stop functioning before the age of 40), depleted estrogen production (caused by low body fat), hypogonadism (occurs when the ovaries or testes don’t produce enough hormone), or osteoporosis.
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