Personal
Professional
Research
Personal Professional Research Sign Up Login Pro Login
Research Diphenyl Phosphate (DPP)
Total Tox-Burden Vibrant Wellness

Diphenyl Phosphate (DPP)

Optimal Result: 0 - 1.1 ug/g.

Diphenyl Phosphate (DPP) is a urinary metabolite that forms when the body breaks down organophosphate flame retardants such as triphenyl phosphate (TPHP), trixylenyl phosphate, and other aryl phosphate esters (APEs). These chemicals are used not only in consumer products like electronics, furniture, and cosmetics but also industrially as catalysts, paint additives, and protective agents in organic synthesis. DPP is measured to assess recent exposure, typically within the past 1–2 days, and elevated levels may indicate absorption through inhalation, skin contact, or ingestion. While originally used to reduce fire risk, these compounds are now linked to concerning health effects. Research shows that DPP may disrupt endocrine signaling, impair cardiac development, and contribute to mitochondrial dysfunction. In addition, DPP has been associated with renal toxicity, liver damage (hepatotoxicity), and blood-related effects (hemotoxicity). Monitoring DPP is especially important for vulnerable populations such as children, pregnant individuals, and those with frequent chemical exposure. Reducing contact with flame-retardant-treated products, improving indoor air quality, and supporting detoxification pathways are key strategies to lower your body burden.

What does it mean if your Diphenyl Phosphate (DPP) result is too high?

Elevated levels of Diphenyl Phosphate (DPP) in urine indicate recent exposure to organophosphate flame retardants, particularly compounds like triphenyl phosphate (TPHP) and other aryl phosphate esters (APEs). Since DPP is a primary metabolite of these chemicals, its presence in urine reflects that the body has absorbed and begun breaking them down—typically within the past 24 to 48 hours. Elevated DPP does not necessarily mean acute toxicity, but it does suggest a measurable body burden of flame retardant chemicals that may have entered through inhalation of indoor air or dust, skin contact with treated materials, or ingestion.

High DPP levels may be of concern due to the potential endocrine-disrupting effects of its parent compounds, especially in sensitive populations such as pregnant individuals, infants, and children. In more chronic or high-level exposures, DPP has been associated with mitochondrial dysfunction, liver and kidney toxicity, hematological effects, and even cardiac development disruption in animal models. Elevated levels can serve as a warning to investigate environmental sources and consider reducing exposure while supporting the body's detoxification systems.

Treatment options for elevated Diphenyl Phosphate (DPP) levels focus on two key goals: eliminating ongoing exposure to organophosphate flame retardants and supporting the body’s natural detoxification pathways. While there is no specific antidote for DPP in non-acute exposures, the following strategies can help reduce body burden and mitigate potential health effects:

1. Remove or Minimize Exposure

  • Replace flame-retardant-treated items: Opt for furniture, mattresses, and baby products labeled as flame-retardant-free.

  • Avoid plastics and electronics with chemical off-gassing: Especially older or damaged items.

  • Improve indoor air quality: Use HEPA filters, ventilate regularly, and reduce dust accumulation.

  • Avoid personal care products with TPHP: Especially certain nail polishes, hair sprays, and cosmetics.

  • Practice good hygiene: Wash hands frequently, especially before meals and after handling electronics or dust-prone items.

2. Support Detoxification Pathways

  • Boost antioxidant capacity:

    • Glutathione (or its precursor NAC – N-acetylcysteine): Supports detoxification and protects mitochondria.

    • Vitamin C and E: Combat oxidative stress caused by toxic metabolites.

  • Enhance liver detoxification:

    • Cruciferous vegetables (e.g., broccoli, Brussels sprouts, kale) support phase II liver detox.

    • Milk thistle (silymarin): A natural liver support herb shown to protect against chemical-induced liver stress.

  • Aid kidney function:

    • Stay well-hydrated to help flush water-soluble toxins like DPP through urine.

  • Support mitochondrial health:

    • CoQ10, alpha-lipoic acid, and B vitamins may help counteract DPP-associated mitochondrial disruption.

  • Promote gut-based detox:

    • A high-fiber diet binds toxins for elimination.

    • Probiotics help maintain gut barrier integrity and support systemic detox.

3. Consider Integrative or Functional Support

  • Work with an environmental medicine or functional health provider: They may run additional tests (e.g., oxidative stress markers, hormone panels) and offer targeted therapies like:

    • Infrared sauna (to promote toxin excretion via sweat)

    • Chelation therapy (in rare cases, if indicated)

    • Targeted supplementation protocols

4. Monitor Over Time

  • Repeat urine testing to track DPP levels after intervention.

  • Screen related systems (e.g., liver enzymes, kidney function, hormones) to monitor potential long-term effects.

Note: If symptoms like fatigue, cognitive fog, hormone imbalances, or unexplained skin, sleep, or mood changes persist, it's worth exploring whether chronic low-level flame retardant exposure could be contributing. Early intervention and lifestyle changes can significantly reduce toxic burden over time.

Frequently asked questions

Healthmatters is a highly-personalized health dashboard.

Instead of searching for your lab results in different places or tracking them down from different providers, Healthmatters houses, organizes, and interprets them all in one central location.

With a Healthmatters account, you can dive into the details of each biomarker and gain insights into the meaning behind your medical test data, anytime, anywhere.

For our professional users, Healthmatters provides intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history.

Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:

  • The GI Effects® Comprehensive Stool Profile,
  • GI-MAP,
  • The NutrEval FMV®,
  • The ION Profile,
  • Amino Acids Profile,
  • Dried Urine Test for Comprehensive Hormones (DUTCH),
  • Organic Acids Test,
  • Organix Comprehensive Profile,
  • Toxic Metals,
  • Complete Blood Count (CBC),
  • Metabolic panel,
  • Thyroid panel,
  • Lipid Panel,
  • Urinalysis,
  • And many, many more.

You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.

If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.

While we work with many popular labs, we welcome reports from lots of other places too.

It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.

If you’re on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.

There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."

Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.

For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.

We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.

Our special data entry service makes it easy to add your results to your private dashboard. Just attach an image or a file of your lab test results, and our skilled data entry team will do the work for you. It's all done by humans, ensuring that your data is entered accurately and with personal care for each client.

Depending on your account, the data entry service can be included for free or come at an additional cost of $15 per report.

For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.

Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.

Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.

The Unlimited plan is a one-time purchase for $250, and it covers your account for a lifetime with no additional payments.

For the Complete plan, the cost is $15 per month. You have the flexibility to cancel it anytime through your account settings, ensuring no further payments. To avoid charges, remember to cancel at least a day before the renewal date. Once canceled, the subscription remains active until the end of the current billing cycle.

Additionally, you can upgrade to the yearly Advanced plan from within your account. The annual cost is $79, and it comes with a data entry service for five reports.

You can always upgrade to a lifetime version with a prorated price from a monthly or yearly subscription.

Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.

Our goal has been to make your Healthmatters account as intuitive as possible.

We’ve crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.

1. Graph View:

Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.

2. All Tests View

Explore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.

3. Table View:

For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.

Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.

Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.

Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.

Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.

A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.

The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.

To learn more about Healthmatters Pro, please refer to the professional page.

Yes, you can! Simply go to the "Invite Doctor" section, enter your doctor’s email address, and send the invitation. Your doctor will receive an email with secure access to view your results. You can revoke this access at any time. All shared information is securely encrypted and protected for your privacy.
Yes, you can! Go to the Graph view or Spreadsheet view. In the top-right corner, click "Export to Excel," and the file will be downloaded to your device.

Use promo code to save 10% off any plan.


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.

Navigate to Total Tox-Burden

Popular search

2,2-bis(4-Chlorophenyl) acetic acid (DDA), 2,4-Dichlorophenoxyacetic Acid (2,4-D), 2-3-4 Methylhippuric Acid (2,-3-,4-MHA), 2-Hydroxyethyl Mercapturic Acid (HEMA), 2-Hydroxyisobutyric Acid (2HIB), 2-Methylhippuric Acid (2MHA), 3-Methylhippuric Acid (3MHA), 3-Phenoxybenzoic Acid (3PBA), 4-Methylhippuric Acid (4MHA), 4-Nonylphenol, Aflatoxin B1 (AFB1), Aflatoxin B2 (AFB2), Aflatoxin G2, Aluminum, Antimony, Atrazine mercapturate, Barium, Beryllium, Bisphenol A (BPA), Bisphenol S (BPS), Butylparaben, Cadmium, Cesium, Chaetoglobosin A (CHA), Citrinin (CTN), Deoxynivalenol(DON), Diethyl phosphate (DEP), Diethyldithiophosphate (DEDTP), Diethylphosphate (DEP), Diethylthiophosphate (DETP), Dihydrocitrinone, Dimethyl phosphate (DMP), Dimethyldithiophosphate (DMDTP), Dimethylthiophosphate (DMTP), Diphenyl Phosphate (DPP), Ethylparaben, Fumonisins B3, Gadolinium, GenX/HPFO-DA, Glyphosate, Mercury, Methylparaben, Mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), Mono-(2-ethyl-5-oxohexyl) phthalate, Mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), Mono-2-ethylhexyl phthalate (MEHP), Mono-2ethylhexyl phthalate (MEHP), Mono-ethyl phthalate (MEtP), Monobutyl phthalate (MBP), Monoethylphthalate (MEP), Monoisobutyl phthalate (MiBP), Mycophenolic Acid, N-Acetyl (2,Hydroxypropyl) Cysteine (NAHP), N-Acetyl (2-Cyanoethyl) Cysteine (NACE), N-Acetyl (3,4-Dihydroxybutyl) Cysteine, N-Acetyl (Carbomethyl) Cysteine (NAE), N-Acetyl (Propyl) Cysteine (NAPR), N-acetyl phenyl cysteine (NAP), N-acetyl-S-(2-carbamoylethyl)-cysteine, Ochratoxin A (OTA), Perchlorate (PERC), Perfluoroheptanoic acid (PFHpA), Perfluoropentanoic acid (PFPeA), Perfluoroundecanoic acid (PFUnA), Phenyl glyoxylic Acid (PGO), Propylparaben, Roridin L2, Sterigmatocystin (STC), Thallium, Thorium, Tiglylglycine (TG), Triclosan (TCS), Tungsten, Verrucarin A, Verrucarin J, Zearalenone (ZEN)