CAR Rise Response

Saliva
Optimal Result: 35 - 60 %.

The "CAR (Cortisol Awakening Response) Rise Response" is a physiological phenomenon observed in the hypothalamic-pituitary-adrenal (HPA) axis, reflecting the body's reaction to stress and its regulatory mechanisms of stress hormones, primarily cortisol.

Upon awakening, a marked increase in cortisol levels is typically observed, peaking within the first 30 to 45 minutes after waking. This response is thought to be an adaptive mechanism that prepares the body for the anticipated demands of the day, enhancing alertness and mobilizing energy resources. The magnitude and pattern of the CAR can be influenced by various factors, including sleep quality, psychosocial stressors, and underlying health conditions. Scientific studies have utilized the CAR as a biomarker for assessing HPA axis function and its dysregulation in stress-related disorders, such as chronic fatigue syndrome, depression, and post-traumatic stress disorder (PTSD).

Furthermore, the CAR has been investigated for its predictive value in health outcomes, including cardiovascular disease and metabolic syndrome, underlining its significance as a critical indicator of physiological stress responses and overall health status. The quantification and analysis of the CAR involve precise measurement of salivary cortisol levels at specific intervals upon waking, requiring standardized collection protocols to ensure accuracy and reliability of the data.

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