Calcium, Ionized, Serum

Electrolytes

A healthy result should fall into the range 4.5 - 5.6 mg/dL.

Calcium is an important mineral found throughout the body. Not only is it important for bone health, but it is important cell communication, blood clotting, muscle contraction, and nerve cell function. The amount of calcium in the body and blood is regulated by several substances including parathyroid hormone, calcitonin, estrogen, and vitamin D, among others. Almost all calcium in the body is found within the bones and teeth. Compared to this, the amount of calcium found outside in the serum is small. However, the amount of calcium found in the serum is an important biomarker. About half of calcium in the blood is bound to proteins and other molecules. However, the other half of blood calcium floats freely in the serum. This free calcium or ionized serum calcium is biologically active and measured directly by the ionized serum calcium test. Serum calcium is usually reported in units of mg/dL in the United States and in mmol/L in many other countries. It may also be reported as mEq/L.

Normal Ranges for ionized calcium:

Men: 4.64 to 5.28 mg/dL

Women: 4.64 to 5.28 mg/dL

Children to up 18 years of age: 4.8 to 5.52 mg/dL

Critical Range: More than 7 mg/dL or less than 2 mg/dL

 

Sources:

http://www.ncbi.nlm.nih.gov/books/NBK279023/

http://www.uptodate.com/contents/regulation-of-calcium-and-phosphate-balance

http://dx.doi.org/10.1038/nrrheum.2012.157

https://www.uptodate.com/contents/relation-between-total-and-ionized-serum-calcium-concentrations

https://www.healthline.com/health/calcium-ionized#results

https://emedicine.medscape.com/article/2087469-overview

https://www.uptodate.com/contents/clinical-manifestations-of-hypocalcemia

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