Optimal Result:
0.1 - 0.5 ug/L.
Sources:
Mushrooms, shellfish, black pepper, parsley, dill seed, beer, wine, grains, sweeteners, infant cereals.
Fossil fuels, welding, catalysts, steel alloys, batteries, photographic developer, drying agent in paints/varnishes, reducing agent, pesticides, black dyes/inks/pigments in ceramics, printing and textile industries.
Absorption factors:
The absorption of V is <5% and most ingested V is found in the stool.
V is transported mainly in the plasma. It is found in large amounts in the blood initially and at trace levels 2 days after exposure.
V has a half-life of around 10 days. Body clearance occurs directly via urinary excretion.
Biochemical actions:
Vanadium mimics insulin and has been used as a supplement for diabetic patients. V stimulates cell proliferation and differentiation. The highest concentrations are found in the liver, kidney and bone.
V is studied in the treatment of diabetes, cancer, and diseases caused by parasites, viruses and bacteria, and for anti-thrombotic, anti-hypertensive, anti-atherosclerotic, and spermicidal properties.
Vanadium-induced cytotoxicity can be mitigated by glutathione, ascorbic acid, or NADH to convert oxidized vanadium (5+) into its reduced (4+) form.
Symptoms of imbalance:
Acute toxicity is rare. V exposure is through ingestion or inhalation. Vanadium may cause abdominal cramps, loose stools, green tongue, fatigue, lethargy, focal neurological issues. Animal studies show renal toxicity with high doses.Urinary vanadium concentrations during pregnancy were associated with preterm delivery and impaired fetal growth. Cardiovascular and respiratory symptoms may be present.
Resources:
Institute of Medicine Panel on M. In: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press (US)
Fatola OI, Olaolorun FA, Olopade FE, Olopade JO. Trends in vanadium neurotoxicity. Brain Res Bull. 2019;145:75-80.
Trevinno S, Diiaz A, Sanchez-Lara E, Sanchez-Gaytan BL, Perez-Aguilar JM, Gonzalez-Vergara E. Vanadium in Biological Action: Chemical, Pharmacological Aspects, and Metabolic Implications in Diabetes Mellitus. Biol Trace Elem Res. 2019;188(1):68-98.
ATSDR. ToxGuide for Vanadium. 2012; https://www.atsdr.cdc.gov/toxguides/toxguide-58.pdf, 2020.
Zwolak I. Protective Effects of Dietary Antioxidants against Vanadium-Induced Toxicity: A Review. Oxid Med Cell Longev. 2020;2020:1490316.
Lab Results Explained and Tracked
What does it mean if your Vanadium result is too high?
Acute toxicity is rare. V exposure is through ingestion or inhalation. Vanadium may cause abdominal cramps, loose stools, green tongue, fatigue, lethargy, focal neurological issues. Animal studies show renal toxicity with high doses.Urinary vanadium concentrations during pregnancy were associated with preterm delivery and impaired fetal growth. Cardiovascular and respiratory symptoms may be present.
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What does it mean if your Vanadium result is too low?
Decreased levels of vanadium on a Metabolomix+ panel, although rare given its trace status in the human body, might not necessarily indicate a health concern due to the uncertain role of vanadium in human physiology. However, understanding the implications of low vanadium levels involves considering several factors:
→ Uncertain Essentiality: Vanadium is not firmly established as an essential nutrient for humans. The biological functions of vanadium in the human body are not fully understood, and there is no clear evidence that a slight deficiency produces clinical symptoms or adverse health outcomes.
→ Dietary Intake: Low levels could potentially reflect a diet that is low in vanadium-containing foods like certain seafood, mushrooms, black pepper, and whole grains. However, because vanadium is needed in such small amounts, its dietary deficiency is extremely rare.
→ Interpretation with Caution: Given the lack of definitive evidence about vanadium’s role in human health, decreased levels are typically not a primary clinical concern. The interpretation of these levels should be cautious and contextual, considering the overall health and nutritional status of the individual.
→ Absorption and Excretion Factors: Factors affecting mineral absorption and excretion, like certain medications, health conditions, or genetic factors, might influence vanadium levels, although this is more speculative due to limited research in this area.
In summary, decreased vanadium levels on a Metabolomix+ panel are generally not regarded as indicative of a health problem, given the current understanding of vanadium's role in human health. However, if there are concerns about mineral balance or overall nutrition, it's advisable to discuss these findings with a healthcare provider for a comprehensive assessment.
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