What is Epstein-Barr Virus p23?
The Epstein-Barr Virus p23 (EBV-p23) marker detects IgG antibodies targeting a specific early antigen (EA-D) protein of the Epstein-Barr Virus (EBV)—a common herpesvirus that infects over 90% of people worldwide.
The p23 protein is part of the early antigen complex, which appears during active viral replication.
IgG antibodies to p23 suggest that your immune system recognizes and has responded to this specific EBV protein.
Elevated IgG to EBV-p23 may indicate:
A recent or reactivated EBV infection, or
Ongoing immune system activation in response to latent virus
Since p23 is part of the early antigen complex, reactivity may reflect:
Viral reactivation under stress or immune suppression
Possible contribution to chronic fatigue, autoimmune activity, or neurological symptoms
This is particularly important on panels like Neural Zoomer Plus, which look for infections or immune responses that may affect brain and nerve function.
While most people carry EBV in a dormant state, reactivation can occur—sometimes without symptoms, and other times with effects such as:
Fatigue or brain fog
Chronic inflammation
Flare-ups in autoimmune conditions (e.g., lupus, MS)
Neurological or psychiatric symptoms (in rare cases)
This marker alone does not diagnose a disease, but a positive or elevated result may be meaningful when:
You have symptoms like fatigue, cognitive decline, or autoimmunity
Multiple EBV antibodies are elevated (e.g., VCA IgG, EBNA IgG, EA-D IgG)
Other infections or neural autoantibodies are also detected
EBV-p23 IgG measures your immune system’s response to an early antigen of Epstein-Barr Virus. Elevated levels may reflect recent infection, chronic reactivation, or persistent immune system engagement with EBV. This marker is most useful when interpreted alongside your symptoms and other immune or neurological biomarkers.
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If your lab report shows that EBV-p23 IgG is elevated, it means your immune system has produced increased levels of antibodies against the p23 protein, which is part of the early antigen complex of the Epstein-Barr Virus (EBV).
It usually indicates past exposure to EBV and that your body is actively recognizing and responding to the virus.
Specifically, the p23 protein is linked to the early phase of viral activity, so elevated levels may suggest:
A recent EBV infection, or
A reactivation of a past infection (which is common, especially during times of stress or immune imbalance)
Most people are exposed to EBV at some point, but the virus stays in the body in a dormant (inactive) state. Sometimes, EBV can reactivate, triggering an immune response. This can happen without noticeable symptoms or may contribute to issues like:
Fatigue or brain fog
Swollen lymph nodes or sore throat
Autoimmune flare-ups
Neurological or cognitive symptoms (in rare cases)
An elevated EBV-p23 IgG:
Does not mean you currently have an active infection like mono, and
Does not diagnose any specific disease, but
It may be relevant if you’re experiencing unexplained symptoms, especially fatigue, immune dysfunction, or neurological changes.
Talk to your healthcare provider about:
Your full EBV antibody profile (e.g., VCA IgG/IgM, EBNA IgG)
Any symptoms you’re having
Whether further evaluation or treatment is needed
An elevated EBV-p23 IgG result means your immune system is reacting to a part of the Epstein-Barr Virus associated with early viral activity. This may reflect a recent or reactivated EBV infection, even if you feel generally well. It’s one piece of a bigger puzzle and should be interpreted with your overall health picture.
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Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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