Immunosciences Lab, Inc.

What is Immunoserology of Lyme? The Immunoserology of Lyme panel is a serum-based test that uses advanced ELISA methodology to detect both active and chronic Lyme disease, including complications such as Lyme arthritis and neuroborreliosis. This panel measures IgM and IgG antibodies against Borrelia burgdorferi and its subspecies (B. afzelii, B. garinii, B. miyamotoi), as well as potential tick-borne co-infections like Babesia, Bartonella, and Ehrlichia. By analyzing antibodies to multiple Borrelia antigens—such as Outer Surface Proteins (OspA, OspB, OspC, OspE), Variable Major Protein (VMP), and Leukocyte Function Associated Antigen (LFA)—the test provides a more precise and reliable diagnosis than standard Lyme assays. Why Accurate Lyme Testing Matters Lyme disease often mimics autoimmune or neurological conditions, making misdiagnosis common. False positives can lead to unnecessary treatment and side effects. False negatives may delay care, increasing the risk of arthritis, meningitis, or long-term neurological complications. By combining cultured Borrelia antigens with proteins expressed in vivo, this immunoserology panel improves diagnostic accuracy and helps distinguish Lyme disease from other inflammatory conditions. When This Panel is Recommended This test may be considered for patients with: History of a tick bite or erythema migrans (rash) Unexplained autoimmune-like symptoms (lupus, rheumatoid arthritis, psoriatic arthritis) Neurological issues (cranial neuritis, meningitis, memory problems, nerve pain) Chronic joint pain or arthritis (Lyme arthritis, chronic synovitis) Immune dysfunction or chronic fatigue Summary Lyme borreliosis is an inflammatory disease affecting multiple organ systems—including the skin, joints, nervous system, heart, and immune system. The Immunoserology of Lyme panel offers a comprehensive and patented ELISA approach to detecting Borrelia infections and related co-infections, guiding earlier and more effective treatment decisions.

Understand your immune system’s response to common and clinically significant viruses The Viral Panel Comprehensive evaluates your body’s immune response to a group of important viruses, including herpesviruses (HSV, HHV-6, EBV), cytomegalovirus (CMV), measles, and varicella-zoster. These pathogens are widespread, and many people are exposed to them during childhood or adolescence. While most infections remain silent or mild, in some individuals they can contribute to chronic symptoms, immune dysregulation, or viral reactivation. This panel measures both IgG (long-term immunity or past exposure) and IgM (recent or active immune response) antibodies. Together, these markers help identify whether your immune system is responding to a current infection, showing evidence of a past infection, or displaying patterns that may suggest viral reactivation. What This Panel Helps You Understand 1. Past Exposure vs. Recent Infection IgG antibodies indicate previous contact with a virus and long-term immune memory. IgM antibodies can signal a more recent or active response. This distinction is essential when evaluating symptoms such as fatigue, swollen lymph nodes, recurrent infections, or suspected viral reactivation. 2. Viral Reactivation Patterns Some viruses—especially Epstein-Barr virus (EBV) and Human Herpesvirus-6 (HHV-6)—can remain dormant and reactivate under certain conditions. Reactivation may contribute to: Chronic fatigue Immune dysfunction Autoimmune processes Neurological symptoms The panel includes markers that help identify possible reactivation, such as EBV Early Antigen or elevated IgM levels in the absence of an acute infection. 3. Immunity Status for Childhood Viruses Markers for measles, varicella-zoster (chickenpox), and CMV help determine whether you have protective immunity or evidence of recent exposure. This is particularly useful for: Children Immunocompromised individuals People evaluating vaccine immunity Anyone with recurrent or unexplained viral symptoms Who This Panel Is Helpful For This panel is often used by clinicians when evaluating: Persistent fatigue, flu-like symptoms, or unexplained malaise Suspected EBV or HHV-6 involvement Immune system dysregulation Chronic inflammatory or autoimmune conditions Recurrent viral infections Immune status in children or adolescents Follow-up after previous abnormal viral titers What the Results Mean Your report will show each viral marker with: Your measured value Reference ranges Whether the result suggests past exposure, active infection, immunity, or reactivation patterns This makes it easier to see how your immune system is interacting with each virus. For example: Negative IgG and IgM → No evidence of prior or current infection Positive IgG, negative IgM → Past infection or immunity Positive IgM → Recent or ongoing immune activity EBV Early Antigen elevation → Possible reactivation High HHV-6 IgM → Possible active or reactivated HHV-6 response Why These Viruses Matter Herpesviruses—such as EBV, CMV, HSV, and HHV-6—establish lifelong latency in the body. For most people this is harmless, but in others these viruses can influence: Energy levels Neurological function Autoimmune activity Susceptibility to other infections Identifying which viruses the immune system is responding to can be an important step in understanding chronic or unexplained symptoms. Takeaway The Viral Panel Comprehensive provides a detailed look at how your immune system interacts with some of the most common and clinically relevant viruses. Whether you’re evaluating new symptoms, monitoring an ongoing condition, or simply confirming immune status, this panel helps provide clarity and direction for next steps.