Naive B cells, characterized as CD19+CD27-IGM+IGD+, are a subset of B cells that have not yet encountered an antigen. Here's a breakdown of their characteristics:
CD19+: This marker signifies that these cells express the CD19 antigen, which is a common B cell marker.
CD27-: Naive B cells lack CD27 expression. CD27 is a marker used to distinguish between memory B cells and naive B cells. The absence of CD27 indicates that these B cells have not undergone the differentiation and class-switching that typically occurs in memory B cells.
IGM+ and IGD+: Naive B cells express both IgM and IgD immunoglobulin isotypes on their surface. IgM and IgD are B cell receptors and are important for antigen recognition. Naive B cells carry both to allow them to respond to a wide range of antigens effectively.
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Elevated production of Naive B Cells with the CD19+CD27-IgM+IgD+ phenotype indicates an increase in a specific subset of B cells in the immune system. Here's what it means:
Naive B Cells: Naive B cells are a subset of B cells that have not encountered antigens (foreign substances like pathogens) and are in their "inexperienced" state.
CD19, CD27, IgM, and IgD: These are surface markers on B cells used to categorize and identify different B cell subsets. In this context:
Elevated Production: An increase in naive B cells with the CD19+CD27-IgM+IgD+ phenotype may suggest an overactive or abnormal immune response. It could be due to various factors, including infections, autoimmune diseases, or other immune system disorders.
Clinical Implications: The clinical significance of elevated production of these B cells depends on the broader context of the individual's health, symptoms, and other diagnostic findings. It may require further evaluation by a healthcare professional to determine the underlying cause and appropriate management.
Note: An elevated production of naive B cells with the CD19+CD27-IgM+IgD+ phenotype suggests an alteration in the immune system, but a definitive interpretation and any necessary actions should be made in consultation with a medical expert, taking into account the individual's specific health condition and medical history.
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Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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