The CA 125 test measures the amount of the protein CA 125 (=cancer antigen 125) in your blood.
A CA 125 test may be used to monitor certain cancers during and after treatment. In some cases, a CA 125 test may be used to look for early signs of ovarian cancer in people with a very high risk of the disease.
A CA 125 test isn’t accurate enough to use for ovarian cancer screening in general because many noncancerous conditions can increase the CA 125 level.
Many different conditions can cause an increase in CA 125, including normal conditions, such as menstruation, and noncancerous conditions, such as uterine fibroids. Certain cancers may also cause an increased level of CA 125, including ovarian, endometrial, peritoneal and fallopian tube cancers.
Why it’s done:
Your doctor may recommend a CA 125 test for several reasons:
- To monitor cancer treatment. If you have ovarian, endometrial, peritoneal or fallopian tube cancer, your doctor may recommend a CA 125 test on a regular basis to monitor your condition and treatment. But such monitoring hasn’t been shown to improve the outcome for those with ovarian cancer, and it might lead to additional and unnecessary rounds of chemotherapy or other treatments.
- To screen for ovarian cancer if you’re at high risk. If you have a strong family history of ovarian cancer or you have the BRCA1 or BRCA2 gene mutation, your doctor may recommend a CA 125 test as one way to screen for ovarian cancer.
- Some doctors may recommend CA 125 testing combined with transvaginal ultrasound every six months for those at very high risk. However, some people with ovarian cancer may not have an increased CA 125 level. And no evidence shows that screening with CA 125 decreases the chance of dying of ovarian cancer. An elevated level of CA 125 could prompt your doctor to put you through unnecessary and possibly harmful tests.
- To check for cancer recurrence. Rising CA 125 levels may indicate that ovarian cancer has come back after treatment. Regular monitoring of CA 125 has not been shown to improve outcomes for those with ovarian cancer and may lead to additional and unnecessary rounds of chemotherapy or other treatments.
If your doctor suspects you may have ovarian cancer or another type of cancer, he or she may recommend a biopsy to collect a sample of cells. Other tests that may be helpful in evaluating these cancers include a transvaginal or pelvic ultrasound, serum human epididymis protein 4 (HE4), and computerized tomography (CT).
Reference ranges:
Results of the CA 125 test are measured in units per milliliter (U/mL). The normal value is less than 46 U/mL.
If you’ve been diagnosed with ovarian, endometrial, peritoneal or fallopian tube cancer, a decreasing CA 125 level often indicates that the cancer is responding to treatment. A rising CA 125 level may indicate a return or continued growth of the cancer.
References:
- CA 125 test (https://www.mayoclinic.org/tests-procedures/ca-125-test/about/pac-20393295)
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The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.
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An elevated CA 125 level may indicate a variety of conditions, ranging from benign to malignant. While high levels are associated with certain cancers, they can also result from numerous noncancerous conditions.
CA 125 levels should always be interpreted alongside other clinical findings and diagnostic tests. A single elevated CA 125 result is not diagnostic of cancer, as levels can fluctuate due to various factors.
If your CA 125 level is elevated, your doctor may recommend:
If your CA 125 level is elevated, consult your healthcare provider for a thorough evaluation and personalized guidance. They can help determine the underlying cause and recommend appropriate next steps.
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Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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Alpha Fetoprotein (AFP), CA 125, CA 15-3, CA 19-9, CA 27.29, CA 72-4, Carcinoembryonic Antigen (CEA), CD19, Chromogranin A (CgA), CYFRA 21-1 (Cytokeratin 19 Fragment), Leukemia/Lymphoma/Myeloma Panel by Flow Cytometry, Matrix Metalloproteinase 9 (MMP 9), MMP-9 (Matrix Metalloproteinase-9), Neuron-specific Enolase (NSE), Neurone Specific Enolase, PapIG, HPV, rfx 16/18, Prostate Cancer Risk Score, Prostate Specific Antigen (PSA), PSA, % Free, S100, Squamous Cell Carcinoma, Total Prostate Specific Antigen (TPSA), Tumor Necrosis Factor-Alpha, Highly Sensitive, Urinary Bladder Cancer Antigen
