CA 125

Other names: Cancer Antigen (CA) 125, Cancer Antigen 125 serum, CA125, CA-125

check icon Optimal Result: 0 - 45.9 U/mL.

The CA 125 test measures the amount of the protein CA 125 (=cancer antigen 125) in your blood.

A CA 125 test may be used to monitor certain cancers during and after treatment. In some cases, a CA 125 test may be used to look for early signs of ovarian cancer in people with a very high risk of the disease.

A CA 125 test isn’t accurate enough to use for ovarian cancer screening in general because many noncancerous conditions can increase the CA 125 level.

Many different conditions can cause an increase in CA 125, including normal conditions, such as menstruation, and noncancerous conditions, such as uterine fibroids. Certain cancers may also cause an increased level of CA 125, including ovarian, endometrial, peritoneal and fallopian tube cancers.

Why it’s done:

Your doctor may recommend a CA 125 test for several reasons:

- To monitor cancer treatment. If you have ovarian, endometrial, peritoneal or fallopian tube cancer, your doctor may recommend a CA 125 test on a regular basis to monitor your condition and treatment. But such monitoring hasn’t been shown to improve the outcome for those with ovarian cancer, and it might lead to additional and unnecessary rounds of chemotherapy or other treatments.

- To screen for ovarian cancer if you’re at high risk. If you have a strong family history of ovarian cancer or you have the BRCA1 or BRCA2 gene mutation, your doctor may recommend a CA 125 test as one way to screen for ovarian cancer.

- Some doctors may recommend CA 125 testing combined with transvaginal ultrasound every six months for those at very high risk. However, some people with ovarian cancer may not have an increased CA 125 level. And no evidence shows that screening with CA 125 decreases the chance of dying of ovarian cancer. An elevated level of CA 125 could prompt your doctor to put you through unnecessary and possibly harmful tests.

- To check for cancer recurrence. Rising CA 125 levels may indicate that ovarian cancer has come back after treatment. Regular monitoring of CA 125 has not been shown to improve outcomes for those with ovarian cancer and may lead to additional and unnecessary rounds of chemotherapy or other treatments.

If your doctor suspects you may have ovarian cancer or another type of cancer, he or she may recommend a biopsy to collect a sample of cells. Other tests that may be helpful in evaluating these cancers include a transvaginal or pelvic ultrasound, serum human epididymis protein 4 (HE4), and computerized tomography (CT).

Reference ranges for CA 125:

Results of the CA 125 test are measured in units per milliliter (U/mL). The normal value is less than 46 U/mL.

If you’ve been diagnosed with ovarian, endometrial, peritoneal or fallopian tube cancer, a decreasing CA 125 level often indicates that the cancer is responding to treatment. A rising CA 125 level may indicate a return or continued growth of the cancer.

References:

- CA 125 test (https://www.mayoclinic.org/tests-procedures/ca-125-test/about/pac-20393295)

Disclaimer:

The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

What does it mean if your CA 125 result is too high?

Elevated CA 125 (Cancer Antigen 125) Levels: What You Need to Know

An elevated CA 125 level may indicate a variety of conditions, ranging from benign to malignant. While high levels are associated with certain cancers, they can also result from numerous noncancerous conditions.


Possible Causes of Elevated CA 125 Levels

Malignant Conditions

  • Ovarian cancer
  • Fallopian tube cancer
  • Endometrial cancer
  • Other intra-abdominal cancers (e.g., pancreatic, stomach, colorectal)

Benign Conditions

  • Endometriosis
  • Pelvic inflammatory disease
  • Uterine fibroids
  • Liver cirrhosis
  • Pregnancy and menstruation
  • Benign ovarian cysts
  • Pancreatitis
  • Chest infections

Interpretation and Further Testing

CA 125 levels should always be interpreted alongside other clinical findings and diagnostic tests. A single elevated CA 125 result is not diagnostic of cancer, as levels can fluctuate due to various factors.

If your CA 125 level is elevated, your doctor may recommend:

  • Ultrasound scans
  • Additional blood tests
  • Imaging studies (e.g., CT or MRI)
  • In some cases, a biopsy

Limitations of CA 125 Testing

  • CA 125 is not recommended as a general screening test for ovarian cancer due to its limited specificity.
  • It is more commonly used to monitor treatment response in known cancer cases or to assess cancer recurrence.

Consult Your Healthcare Provider

If your CA 125 level is elevated, consult your healthcare provider for a thorough evaluation and personalized guidance. They can help determine the underlying cause and recommend appropriate next steps.

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