AChR Binding Abs, Serum

check icon Optimal Result: 0 - 0.24 nmol/L.

What Is the AChR Binding Antibodies Test?

The AChR Binding Antibodies, Serum test measures the presence of autoantibodies against acetylcholine receptors (AChRs) in the blood. These antibodies interfere with the normal communication between nerves and muscles and are commonly associated with myasthenia gravis (MG) — a chronic autoimmune disorder that causes muscle weakness and fatigue.

This test specifically looks for binding antibodies, the most common type found in people with MG.

Why Is This Test Important?

Acetylcholine is a chemical messenger that tells your muscles to contract. In myasthenia gravis, the immune system produces antibodies that block or destroy the acetylcholine receptors on muscle cells, preventing proper muscle activation. Detecting AChR binding antibodies in the blood helps confirm the diagnosis and guides treatment decisions.

Who Should Get This Test?

Your doctor may recommend this test if you experience symptoms such as:

  • Drooping eyelids (ptosis)

  • Double vision (diplopia)

  • Muscle weakness that worsens with activity

  • Difficulty swallowing, speaking, or breathing

  • Fatigue in the arms, legs, or neck

It may also be used to monitor disease progression or response to therapy in people already diagnosed with MG.

What Do the Results Mean?

  • Positive Result:
    A positive test means AChR binding antibodies are present, supporting a diagnosis of autoimmune myasthenia gravis. Most individuals with generalized MG will test positive. This finding helps confirm that symptoms are due to an autoimmune attack on acetylcholine receptors.

  • Negative Result:
    A negative result means that AChR binding antibodies were not detected, but this does not fully rule out myasthenia gravis. Some people with MG may have other types of antibodies, such as MuSK or LRP4 antibodies, or may test negative altogether (seronegative MG). Additional testing may be necessary.

How Is the Test Performed?

This test requires a blood sample taken from a vein in your arm. No fasting or special preparation is needed beforehand.

Summary

The AChR Binding Antibodies, Serum test is a key diagnostic tool for myasthenia gravis, helping identify the autoimmune attack on the neuromuscular system. A positive result can confirm the diagnosis and allow for earlier, more targeted treatment to manage symptoms and improve quality of life.

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