Other names: 2,3-dinor 11B-Prostaglandin F2a, U
Optimal Result:
0 - 5205 pg/mg Cr.
2,3-dinor-11β-PGF2α is a urinary metabolite of prostaglandin D2 (PGD2)—a lipid mediator produced from arachidonic acid via the cyclooxygenase (COX) pathway. Mast cells are a major source of PGD2. After PGD2 is released in tissues, it is rapidly converted into more stable downstream metabolites, including 11β-PGF2α and 2,3-dinor-11β-PGF2α, which are excreted in urine. Measuring these metabolites provides a noninvasive index of in-vivo PGD2 production and, by extension, mast-cell activation.
Also known as:
2,3-dinor-11β-PGF2α (urine)
Dinor-11β-PGF2α, U
PGD2 metabolite (urine)
u-PGD2-M (terminology varies by lab)
PGD2 is a potent bioactive mediator that can cause bronchoconstriction, vasodilation, increased vascular permeability, flushing, and nasal congestion. Elevated urinary PGD2 metabolites are therefore used as supportive evidence in conditions featuring mast-cell activation, such as:
Mast Cell Activation Syndrome (MCAS) and systemic mastocytosis
Aspirin-exacerbated respiratory disease (AERD) / NSAID-exacerbated respiratory disease
Allergic reactions and anaphylaxis (often transient spikes)
Chronic spontaneous urticaria, atopic asthma, allergic rhinitis
Some cutaneous mastocytosis flares and food/venom allergies during reactions
Important: This marker is supportive, not diagnostic on its own. It is typically interpreted alongside clinical symptoms and companion markers (e.g., serum tryptase, urinary N-methylhistamine, urinary leukotriene E4 [uLTE4]).
Specimen: Urine (often a spot sample normalized to creatinine; some centers may request a 24-hour collection).
Method: Usually LC-MS/MS for specificity and sensitivity.
Reporting units: Commonly pg/mg creatinine or ng/mmol creatinine (varies by laboratory).
Stability/handling: Keep cool; follow lab instructions carefully—improper handling can affect results.
There is no universal cut-off. Reference intervals and decision thresholds vary by lab, assay, and whether the sample is a spot vs. 24-hour collection. Always compare your value with the lab’s own reference range on the report.
Suggests increased PGD2 pathway activity, commonly due to mast-cell activation. Consider the clinical context:
Symptoms consistent with mast-cell mediator release (flushing, wheeze/bronchospasm, nasal congestion/rhinorrhea, abdominal cramping/diarrhea, hypotension during reactions).
Co-elevations in urinary N-methylhistamine, uLTE4, or a rise in serum tryptase during episodes (Δ tryptase ≥20% + 2 ng/mL over baseline supports mast-cell involvement).
Recent allergen exposure, anaphylaxis, or NSAID challenge in AERD can produce transient spikes.
Non-disease contributors / confounders (can raise or alter levels):
Medications:
COX inhibitors (NSAIDs, high-dose aspirin) generally suppress prostaglandin synthesis; however, in AERD, reactions to aspirin/NSAIDs are complex and can be accompanied by transient mediator surges during provocation.
Corticosteroids and mast-cell stabilizers (e.g., cromolyn) may lower levels over time.
Active infections, acute inflammation, or vigorous allergic exposure shortly before sampling.
Collection timing relative to symptom flares (levels can be episodic).
What to do next (clinically, with your clinician):
Correlate with symptom diary and consider paired sampling: one sample during/just after a flare and one baseline when asymptomatic.
Review companion markers (tryptase, uLTE4, N-methylhistamine).
Evaluate medication effects (NSAIDs, steroids, biologics like omalizumab, dupilumab; leukotriene modifiers).
If mast-cell disease is suspected, consider referral to allergy/immunology or hematology (for systemic mastocytosis evaluation when indicated).
A normal value does not exclude mast-cell activation—mediator release can be intermittent and time-sensitive to flares. If suspicion remains high, clinicians often:
Repeat testing during symptoms,
Check other mediators, and
Assess tryptase dynamics (baseline vs. event-related rise).
Usually of limited standalone significance. Very low levels may reflect COX inhibition (e.g., steady NSAID use) or effective anti-inflammatory / anti-mast-cell therapy.
Because no single mediator fits all patients or all timepoints, clinicians often combine:
Serum tryptase (baseline and during events),
Urinary leukotriene E4 (uLTE4) for cysteinyl-leukotriene pathway activity,
Urinary N-methylhistamine (histamine turnover),
Prostaglandin metabolites like 2,3-dinor-11β-PGF2α and 11β-PGF2α (PGD2 pathway).
This multi-analyte approach improves sensitivity for detecting mast-cell involvement.
Timing: Collect as close to symptom onset as practical (often within 4–6 hours) for flare assessment.
Diet & supplements: Typically minimal effect, but always follow lab prep instructions.
Meds: NSAIDs/aspirin, COX-2 inhibitors, corticosteroids, mast-cell stabilizers, and certain biologics can shift levels (direction depends on drug and clinical context). Share a full med list with your clinician.
Renal function & hydration: Creatinine-normalized reporting helps, but extreme hydration or renal impairment can still affect interpretation.
Support diagnosis of mast-cell–mediated conditions in the right clinical setting.
Document objective mediator release in patients with unexplained flushing, anaphylactoid episodes, or bronchospasm.
Monitor response to therapy (e.g., after starting leukotriene modifiers, cromolyn, antihistamines, or biologics) when measured consistently with the same lab/method.
Ask whether your lab prefers a first-morning spot urine (with creatinine) or a 24-hour collection.
If evaluating flares, plan to collect during symptoms and consider a baseline sample on a stable day.
Verify units and reference range on your specific report; keep copies for comparison over time.
If you’re on medications that may affect prostaglandins, do not stop them without medical guidance—interpretation can account for them.
Is this the same as 8-iso-PGF2α (F2-isoprostanes)?
No. F2-isoprostanes are markers of oxidative stress formed non-enzymatically. 2,3-dinor-11β-PGF2α reflects enzymatic PGD2 pathway activity, often tied to mast-cell activation.
Do I need both 11β-PGF2α and 2,3-dinor-11β-PGF2α?
Many labs measure one or both. Patterns can be informative, but either can serve as a surrogate for PGD2 production. Use the same lab and method for trend monitoring.
What’s a “good” level?
“Good/abnormal” depends on the lab-specific reference interval and your clinical picture. Elevated values are only actionable when correlated with symptoms and other markers.
Import lab results from multiple providers, track changes over time, customize your reference ranges, and get clear explanations for each result. Everything is stored securely, exportable in one organized file, and shareable with your doctor—or anyone you choose.
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Our user-friendly form guides you through a quick, simple submission process, making it easy to enter your health metrics.
Add your results anytime with our easy entry form. It's quick, guided, and helps you stay organized — free for all members.
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View your lab data through easy-to-read graphs and tables. Quickly spot patterns, track changes, and compare results across different dates — all without digging through multiple reports. You can also select and compare graphs of specific biomarkers side-by-side to better understand how they relate and change over time.
See your lab reports in clear graphs and tables. Spot patterns, track changes, and compare results over time — all in one place.
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Export Your Complete Lab History
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After collecting lab results from different providers, you can download your entire history combined into a single file.
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Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest. Complete plan members receive one report entered for free, then $15 per report after that. Unlimited plan members receive ten report entries for free, then $15 per report after that.
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest.
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Whether you're working with a doctor, nutritionist, caregiver, or wellness coach, you can securely share your complete lab history by sending an invite link to anyone you trust. You have full control over who sees your information and for how long, ensuring your privacy and peace of mind at every step.
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As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
With a Healthmatters account, you can:
Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you're on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
The Complete Plan ($15/month) is perfect for individuals who want ongoing access to their health data. It includes unlimited lab imports, visual tracking, custom ranges, result explanations, full account exports, and secure sharing — all with a simple monthly subscription. You can cancel anytime and restart your plan whenever you're ready — your data will still be there waiting for you. You can also upgrade to the Unlimited Plan at any time, with the cost prorated based on what you've already paid.
The Unlimited Plan ($250 one-time) is also designed for individuals but offers lifetime access with no ongoing subscription. You'll get all the same features as the Complete Plan, plus a larger initial data entry allowance (10 reports), making it a great choice if you prefer a one-time payment and long-term use without monthly fees.
In short:
There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
Prefer to do it yourself? You can always use our free self-entry tool to add results manually — it just takes a bit more time and attention.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
The Pro Monthly Plus plan is priced at $75 per month and includes a data entry service for five reports each month. Additional reports can be self-entered at no extra cost or, if preferred, you can use our data entry service for an additional fee of $15 per report.
The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
You also have the option to upgrade to higher monthly or to annual plans, which come with substantial discounts. All upgrades can be done directly from your account.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Our goal has been to make your Healthmatters account as intuitive as possible.
We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewExplore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Yes, you can download your information anytime. We offer two easy ways to export your lab data:
This makes it simple to save, back up, or share your health data whenever you need.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
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