Other names: Xanthurenic Acid
Xanthurenate is formed from an amino acid that comes from protein in your diet. High levels can indicate an insufficiency of B6, a vitamin critical for all protein metabolism. Use of medications (e.g., oral contraceptives, anti-hypertensives, and bronchodilators) and exposure to tobacco smoke, pesticides, and other agricultural products can all contribute to insufficiency of vitamin B6. Problems with balance, fatigue, and mental/emotional stability (such as PMS and ADHD) are frequently found in patients with inadequate vitamin B6. Research has shown that symptoms of autism can be ameliorated with vitamin B6 supplementation. Additionally, xanthurenate can prevent insulin from performing its vital role in blood sugar regulation, which can contribute to diabetes.
If elevated, it reflects insufficient Vitamin B6.
High levels can indicate an insufficiency of B6, a vitamin critical for all protein metabolism. Use of medications (e.g., oral contraceptives, anti-hypertensives, and bronchodilators) and exposure to tobacco smoke, pesticides, and other agricultural products can all contribute to insufficiency of vitamin B6.
Symptoms of vitamin b6 deficieny:
Changes in mood, such as irritability, anxiety and depression, confusion, muscle pains, low energy, or fatigue.
Food high in B6 include pinto beans, avocado, pistachios, sesame and sunflower seeds. Supplementation may be advised.
If levels of estrogen or cortisol are high, it may exacerbate xanthurenate elevations and increase the need for B6. Xanthurenate complexes with insulin and decreases insulin sensitivity. Xanthurenate can also bind to iron and create a complex that increases DNA oxidative damage resulting in higher 8-OHdG levels. If both markers are elevated, there is likely an antioxidant insufficiency.
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