Vasopressin is also referred to as ADH. ADH is made by your hypothalamus. ADH keeps the amount of water in your body in balance. Certain conditions can affect the amount of ADH that your body makes. These include hyponatremia, or low sodium levels in your bodily fluids. They also include diabetes insipidus. Symptoms of this condition include urinating often and being very thirsty.
A lower-than-normal level may indicate:
- Damage to the hypothalamus or pituitary gland
- Central diabetes insipidus (condition in which the kidneys are not able to conserve water)
- Excessive thirst (polydipsia)
- Too much fluid in the blood vessels (volume overload)
A higher-than-normal level may occur when too much ADH is released, either from the brain where it is made, or from somewhere else in the body. This is called syndrome of inappropriate ADH (SIADH).
Causes of SIADH include:
- Brain injury or trauma
- Brain tumors
- Fluid imbalance after surgery
- Infection in the brain or the tissue that surrounds the brain
- Infection in the lungs
- Certain medicines, such as some seizure drugs, pain medicines, and antidepressants
- Small cell carcinoma lung cancer
A higher-than-normal level of ADH may be found in people with heart failure, liver failure, or some kinds of kidney disease.
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