Optimal Result:
0.04 - 0.3 ug/L.
Some studies suggest vanadium has a role in glucose and lipid metabolism, red blood cell formation, and thyroid function. Vanadium assessment and treatment may be indicated in cases of metabolic syndrome or non-insulindependent diabetes mellitus due to vanadium’s role in insulin sensitization. Symptoms that appear to be associated with excessive vanadium are hypertension, decreased coenzymes A and Q10, bipolar disorder, and disruption of energy metabolism. Exposure to vanadium in air or water is of concern for those exposed to vanadium industrial plants. Symptoms may include respiratory disorders, green tongue, high urinary excretion of vanadium, and reduced neurobehavioral abilities. Urine vanadium is traditionally used to assess occupational exposure. Whole blood vanadium has been shown to significantly differentiate children with vanadium exposure from non-exposed children but authors stated that hair levels of vanadium did not significantly correlate with vanadium exposure. This may have to do with distinction of acute versus chronic exposure.
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What does it mean if your Vanadium result is too low?
Vanadium is not currently considered an essential nutrient cofactor for any human enzyme, although it is essential for some rodents (rats). Vanadium may improve insulin responses and blood sugar control; Wang et al. (2014) found an inverse correlation in new type II Chinese diabetics and plasma V levels. The subjects with the lowest levels of V had the highest risk of diabetes.
Accumulating evidence suggests that the presence or absence of V may alter immune responses, particularly humoral immunity (B cell responses). A study of industrial workers indicates that low levels of V may be associated with increased risk for atherosclerosis (higher cholesterol, lower HDL-C, poor apoB / apoA1 ratios); this association was strongest in males. Very little V is found in red blood cells.
The oxidation state of V may determine whether it is found in the cell or the plasma. Vanadium (IV) diffuses through cell membranes, while V enters cells via anionic channels. Intracellular V is found primarily in the kidneys, spleen, bones and liver, and is typically found as vanadium (IV) or V. In the plasma, V is primarily bound to transferrin, albumin or serum lipids.
Normal serum concentrations in unexposed human populations average less than 1û2 µg V/L.
Consider:
-Evaluate digestion and absorption (Comprehensive Stool Analysis)
-Evaluate diet. Food sources of V include: mushrooms, shellfish, black pepper, parsley, dill weed, grain and grain products.
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