Levels of pyrimidine metabolites (uracil and thymine) reflect how well the body is metabolizing folate.
A body deficient in folate (vitamin B9) has high uracil levels. Other causes of high uracil levels include mutations to the MTHFR homozygous gene and issues with methylation.
- Because folic acid is involved as a methyl donor in the conversion of uracil to thymine, elevated uracil may indicate a defect in folic acid metabolism.
- High levels of Uracil can indicate a folate deficiency, it can also indicate methylation problems and this is more likely to be an issue for people with the MTHFR gene mutation.
- Elevated uracil is found in about 10% of children with autism.
- If Uracil is high consider additional L-Methyl-Folate supplementation, i.e. 500mcg to 1000mcg daily.
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