Sterigmatocystin
Sterigmatocystin (STG) is a mycotoxin that is closely related to aflatoxin. STG is produced from several species of mold such as Aspergillus, Penicillium, and Bipolaris. It is considered to be carcinogenic, particularly in the cells of the GI tract and liver. STG has been found in the dust from damp carpets. It is also a contaminant of many foods including grains, corn, bread, cheese, spices, coffee beans, soybeans, pistachio nuts, and animal feed. In cases of lung aspergilloma, STG has been found in human tissue specimens. The toxicity of STG affects the liver, kidneys, and immune system. Tumors have been found in the lungs of rodents that were exposed to STG. Oxidative stress becomes measurably elevated during STG exposure, which causes a depletion of antioxidants such as glutathione, particularly in the liver.
References:
Viegas, C.; Nurme, J.; Pieckova, E.; S, V., Sterigmatocystin in foodstuffs and feed: aspects to consider. Mycology 2018, 2018. [L]
What does it mean if your Sterigmatocystin result is too high?
Sterigmatocystin, a related dihydrofuran toxin, is a late metabolite in the aflatoxin pathway and is also produced as a final biosynthetic product by a number of species such as Aspergillus Penicillium, and Bipolaris. STC is a possible human carcinogen (2B) according to IARC classification and showed immunotoxic and immunomodulatory activity, together with mutagenic effects. It might be found in numerous substrates, from foods and feeds to chronically damp building materials and indoor dust.
Due to the structural similarities, aflatoxins and STC share relevant toxic effects, including genotoxicity and carcinogenicity. However, in contrast to aflatoxins, only limited information on occurrence and toxicity of STC is available. Liver and kidneys are the target organs of acute toxicity of STC. However, the acute oral toxicity is relatively low (range between 120 and 166 mg/kg body weight).
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