Selenium

Sample type: BLOOD - Red Cell
Optimal result: 190 – 500 ug/L

Selenium toxicity symptoms include hair and nail, brittleness and loss (selenosis), G.I. disturbances, skin rash, garlic, breath, odor, fatigue, irritability, and nervous system abnormalities.

Symptoms of selenium deficiency occur in extreme cases of deprivation and include necrotizing cardiomyopathy, peripheral myopathy, decreased muscle tone, thinning hair, opaque nails, and anemia. The disease associated with selenium deficiency is called Keshan disease. Selenium deficiency may be a cancer promoting factor.

Sources:

The selenium content of grains and vegetables depends on the selenium content of the soil. In meats, selenium content is dependent on the diet of the animals. Foods with higher selenium content include Brazil nuts, seafood (especially tuna), chicken, beef, pork, lamb. Also present in air, water, soil, metallurgy, airborne coal/oil emissions, dandruff shampoo, paints, photo cells, drums, photocopiers, glass, ceramics, rubber, pharmaceuticals.

Absorption factors:

Selenium tends to be well absorbed, and the bioavailability of selenium in the form of selenomethionine is greater than 90%. Sulfur, lead, arsenic, calcium and iron reduced the absorption of selenium. Urine is the main route of excretion and reflects recent dietary intake. Plasma is useful for assessing nutritional selenium status.

Sources:

The selenium content of grains and vegetables depends on the selenium content of the soil. In meats, selenium content is dependent on the diet of the animals. Foods with higher selenium content include Brazil nuts, seafood (especially tuna), chicken, beef, pork, lamb. Also present in air, water, soil, metallurgy, airborne coal/oil emissions, dandruff shampoo, paints, photo cells, drums, photocopiers, glass, ceramics, rubber, pharmaceuticals.

Absorption factors:

Selenium tends to be well absorbed, and the bioavailability of selenium in the form of selenomethionine is greater than 90%. Sulfur, lead, arsenic, calcium and iron reduced the absorption of selenium. Urine is the main route of excretion and reflects recent dietary intake. Plasma is useful for assessing nutritional selenium status.

Biochemical reactions:

Selenium is a part of selenoproteins that are important for antioxidant defense, thyroid hormone formation, DNA synthesis, and reproduction. Deiodinases in the thyroid incorporate selenium and I'm important for conversion of thyroxine to active T3. Glutathione peroxidase is a selenium-dependent antioxidant enzyme that neutralizes hydrogen peroxide. Some research suggest that plasma glutathione peroxidase levels may be a good indicator of selenium status.

Selenium
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