Sarcosine is also known as N-methylglycine. It is an intermediate and byproduct in the glycine synthesis and degradation. Sarcosine is metabolized to glycine by the enzyme sarcosine dehydrogenase, while glycine-N-methyl transferase generates sarcosine from glycine. It is an intermediate and byproduct in the glycine synthesis and degradation. Sarcosine is metabolized to glycine by the enzyme sarcosine dehydrogenase, while glycine-N-methyl transferase generates sarcosine from glycine. Sarcosine is a natural amino acid found in muscles and other body tissues. Sarcosine is found naturally as an intermediate in the metabolism of choline to glycine. Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1), an N-methyl-D-aspartate receptor (NMDAR) co-agonist, and an important intermediate in one-carbon metabolism.
- Elevated urine sarcosine has been associated with the incidence of type 2 diabetes.
- Blood sarcosine has been proposed as a biomarker of diet restriction and older age.
- Sarcosine supplementation has shown beneficial effects in schizophrenia.
- Krill oil supplementation increased fasting plasma sarcosine, along with betaine and choline.
- Metabolism requires B2. May indicate functional B2 deficiency.
- Suspect increased need for folic acid if: Elevated HOMOCYSTINE, SARCOSINE, glycine, serine, 1-methylhistidine, 3-methylhistidine, methionine, cystathionine or histidine.
- Could also be Sarcosinemia, a rare autosomal recessive metabolic disorder. It can result from an inborn error of sarcosine metabolism, or from severe folate deficiency. It is thought to be a relatively benign condition.
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1-Methylhistidine, 2-Methylhippuric Acid, 2-Methylsuccinic Acid, 3,4-Dihydroxyhydrocinnamic Acid, 3,5-Dihydroxybenzoic Acid, 3-Methylhistidine, 3-Phenylpropionylglycine, 4-Hydroxybenzoic Acid, 4-Hydroxyphenylacetic Acid, 4-Hydroxyphenylpyruvic Acid, 5-Hydroxyindoleacetic Acid, 8-Hydroxy-2'-deoxyguanosine, a-Hydroxybutyric Acid, a-Ketoglutaric Acid, a-Ketoisovaleric Acid, a-Aminoadipic Acid, a-Keto-b-methylvaleric Acid, a-Ketoglutaric Acid, a-Ketoisocaproic Acid, Adipic Acid, Alanine, Anserine, Anthranilic Acid, Arabinitol, Arginine, Arginosuccinic Acid, Asparagine, Aspartic Acid, b-Hydroxybutyric Acid, b-Alanine, b-Hydroxyisovaleric Acid, Benzoic Acid, Benzoylform, Branched Chain Alpha-Keto Organic Acids, Carnosine, cis-Aconitic Acid, Citric Acid, Citrulline, Cortisol, Creatinine, Cystathionine, Cystine, Equol, Ethanolamine, Ethylmalonic Acid, Formiminoglutamic Acid, Fructose, Fumaric Acid, g-Aminobutyric Acid, Glucaric Acid, Glucose, Glutamic Acid, Glutamine, Glutamine / Glutamate Ratio, Glutaric Acid, Glycine, Glycylproline, Hexanoylglycine, Hippuric Acid, Histidine, Homocitrulline, Homocystine, Homogentisic Acid, Homovanillic Acid, Hydroxykynurenine, Hydroxyproline, Indoleacetic Acid, Isocitric Acid, Isoleucine/allo-Isoleucine, KT Ratio, Kynurenic Acid, Kynurenine, Lactic Acid, Leucine, Lysine, Malic Acid, Mandelic Acid, Methionine, Methylmalonic Acid, Microalbumin, Ornithine, Orotic Acid, Oxalic Acid, Phenylacetic Acid, Phenylalanine, Phosphate, Phosphoethanolamine, Picolinic Acid, Pimelic Acid, Proline, Pyridoxic Acid, Pyroglutamic Acid, Pyruvic Acid, Quercetin, Quinolinic Acid, Sarcosine, Serine, Suberic Acid, Suberylglycine, Succinic Acid, Sulfocysteine, Tartaric Acid, Taurine, Threonine, Total Branched Chain Amino Acids, Tryptophan, Tyrosine, Valine, Vannilylmandelic Acid, Xanthurenic Acid
