Saccharomyces cerevisiae, IgA
Optimal Result:
0 - 20 Units.
Saccharomyces cerevisiae IgA antibodies are found in about 35% of CD patients but less than 1% in UC patients. Detection of both Saccharomyces IgG and IgA antibodies in the same serum specimen is highly specific for CD.
Anti-Saccharomyces cerevisiae antibodies (ASCA) are immune proteins found in people with inflammatory bowel disease (IBD), which is a chronic condition characterized by swollen and damaged tissues in the intestinal tract. The ASCA test detects these antibodies in the blood.
Saccharomyces cerevisiae, also known as S. cerevisiae, is a common type of yeast found in various foods. The relationship between the presence of S. cerevisiae antibodies and their involvement in the development of inflammatory bowel disease is currently not understood.
IBD can vary in symptoms and severity from person to person. It often involves flare-ups followed by periods of reduced symptoms or remission. The two main types of IBD are Crohn disease (CD) and Ulcerative colitis (UC). CD can affect any part of the intestinal tract, primarily the small intestine and/or colon, while UC specifically occurs in the colon.
Diagnosing CD or UC typically involves endoscopic testing and examining biopsy samples from the intestines. Since both CD and UC can affect the colon, it can be challenging to differentiate between the two using biopsies alone. In such cases, ASCA testing may be helpful because ASCA is more frequently found in people with CD compared to those with UC.
The body produces two classes of Saccharomyces cerevisiae antibodies, ASCA IgG and ASCA IgA. The testing usually includes both classes. ASCA IgG levels can potentially indicate the severity of the disease and the need for surgery as a treatment option.
Lab Results Explained and Tracked
What does it mean if your Saccharomyces cerevisiae, IgA result is too high?
Saccharomyces cerevisiae IgA antibodies are found in about 35% of CD patients but less than 1% in UC patients.
A positive ASCA (Anti-Saccharomyces cerevisiae antibodies) result is not diagnostic of CD, UC, or of an IBD, but it does make it more likely that a person with symptoms has an IBD.
Results of ASCA testing are often interpreted in conjunction with the results of pANCA testing:
- If ASCA is positive and pANCA is negative, then it is likely that the person has Crohn disease (CD).
- If ASCA is negative and pANCA is positive, then it is likely that the person has Ulcerative colitis (UC).
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