Parabacteroides
Parabacteroides is a genus of Gram-negative, anaerobic bacteria that naturally resides in the human gastrointestinal tract, particularly in the colon. It is considered a commensal organism and plays an important role in maintaining gut homeostasis through its involvement in immune modulation, metabolic processes, and microbial balance.
Parabacteroides species participate in bile acid metabolism, carbohydrate fermentation, and signaling pathways that influence inflammation and immune tolerance. In balanced amounts, this genus is generally associated with anti-inflammatory effects and metabolic stability. Research has linked healthy Parabacteroides abundance to improved insulin sensitivity, reduced inflammatory signaling, and better gut barrier function.
Low Parabacteroides levels may indicate reduced microbial diversity, impaired metabolic capacity, or a loss of anti-inflammatory support within the gut. This pattern has been observed in individuals with metabolic dysfunction, inflammatory bowel conditions, obesity, or chronic low-grade inflammation.
Elevated Parabacteroides levels, while not inherently pathogenic, may reflect compensatory microbial shifts or dysbiosis depending on the broader microbiome context. In some cases, higher levels have been associated with altered bile acid metabolism or inflammatory states when seen alongside other imbalanced bacteria.
On the Gut Zoomer panel, Parabacteroides is interpreted in relation to overall microbiome diversity, inflammatory markers, short-chain fatty acid pathways, and gut barrier integrity. Its value lies in what it reveals about immune–metabolic balance rather than acting as a standalone diagnostic marker.
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What does it mean if your Parabacteroides result is too low?
Low Parabacteroides levels may reflect diminished anti-inflammatory support, reduced microbial diversity, or impaired metabolic signaling within the gut. When combined with other low commensal bacteria, this pattern can indicate increased susceptibility to inflammation or metabolic imbalance.
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