Mo is an essential nutrient that functions as an obligatory cofactor for the iron- and flavin-containing enzymes aldehyde oxidase, xanthine oxidase, and sulfite oxidase. Aldehyde oxidase oxidizes and detoxifies the pyrimadines, purines, and pteridines. Xanthine oxidase/ dehydrogenase catalyzes the formation of uric acid from hypoxanthine and sulfite oxidase catalyzes the transformation of sulfite to sulfate. Insufficient sulfite oxidase activity can result in deranged cystiene metabolism.
References:
- Nielsen, F.H. Ultratrace Minerals, chapter 15 in Modern Nutrition in Health and Disease, 8th ed., vol. 1, Lea & Febiger, 1994.
- Falchuk, K.H. Disturbances in Trace Elements, in Fauci, A.S. et. al., eds, Harrison’s Principles of Internal medicine, 14th edition, Mc Graw Hill, 1998.
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What does it mean if your Molybdenum result is too low?
Mo is an essential nutrient that functions as an obligatory cofactor for the iron- and flavin-containing enzymes aldehyde oxidase, xanthine oxidase, and sulfite oxidase. Aldehyde oxidase oxidizes and detoxifies the pyrimadines, purines, and pteridines. Xanthine oxidase/ dehydrogenase catalyzes the formation of uric acid from hypoxanthine and sulfite oxidase catalyzes the transformation of sulfite to sulfate. Insufficient sulfite oxidase activity can result in deranged cystiene metabolism.
Mo is readily absorbed (40 - 80%) and transported as a complex with protein in blood. Blood levels of Mo are regulated primarily by urinary excretion. Recent surveys indicate that many diets do not provide the recommended safe and adequate intake of 50 - 350 mcg Mo/day. Good sources of Mo include milk products, whole grains, dried legumes, and organ meats.
Symptoms of overt Mo deficiency have only been described for a patient on long-term total parenteral nutrition. However, prolonged exposure to tungsten (T.I.G. welding) or dietary sulfates, aldehydes, and large amounts of purines in the diet might possibly result in an acquired Mo deficiency. A possible link between Mo deficiency and increased risk for esophageal cancer has been reported. Mo deficiency would be expected to be associated with abnormally low levels of uric acid in blood and sulfate in urine.
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