Milk Butyrophilin
Optimal Result:
0 - 1.4 ELISA Index.
Antigen Made From:
Milk Butyrophilin purchased from an antigen supplier
Associated With:
- Multiple sclerosis
- Sjögren’s syndrome
- Systemic lupus erythematosus
Known Cross-Reactions:
Myelin oligodendrocyte glycoprotein, Gliadin, Insulin
Clinical Significance:
The presence of antibodies to Milk Butyrophilin is an indication of food immune reactivity. The offending food and its known cross-reactive foods should be eliminated from the diet. Milk Butyrophilin has a far reaching effect on the body. It can stimulate antigen-specific immune responses in both gut-associated lymphoid tissue (GALT) and peripheral immune organs, and it exacerbates central nervous system inflammation.
Milk Butyrophilin shares a similar homology to myelin and has been shown to degrade myelin tissues through molecular mimicry and cross-reactivity. Patients exhibiting neurological disorders should therefore abstain from consuming milk products.
References:
1. Guggenmos et al. Antibody cross-reactivity between MOG and the milk protein butyrophilin in multiple sclerosis. J Immunol. 2004; 172:661-668.
2. Mather and Jack. A review of the molecular and cellular biology of butyrophilin, the major protein of bovine milk fat globule membrane. J Dairy Sci, 1993; 76:3832-3850.
3. Stefferl et al. Butyrophilin, a milk protein, modulates the encephalitogenic T cell response to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis. J Immunol, 2000; 165:2859-2865.
4. Vojdani and Tarash. Cross-reaction between gliadin and different food and tissue antigens, Food Nutri Sci, 2013; 4:20-32.
5. Kennel De March et al. Anti-myelin oligodendrocyte gloycoprotein B-cell responses in multiple sclerosis. J Neuroimmunol, 2003; 135(1-2):117-125.
6. Lauer. Diet and multiple sclerosis. Neurology, 1997; 49(Suppl 2):S55-S61.
7. Vojdani et al. Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumonia and Streptococcus group A. J Neuroimmunol, 2002; 129:168-177.
8. Kharrazian, et al. Detection of islet cell immune reactivity with low glycemic index foods: is this a concern for type 1 diabetes. J Diabetes Res, 2017; 2017:4124967.
Lab Results Explained and Tracked
What does it mean if your Milk Butyrophilin result is too high?
The presence of antibodies to Milk Butyrophilin is an indication of food immune reactivity. The offending food and its known cross-reactive foods should be eliminated from the diet. Milk Butyrophilin has a far reaching effect on the body. It can stimulate antigen-specific immune responses in both gut-associated lymphoid tissue (GALT) and peripheral immune organs, and it exacerbates central nervous system inflammation.
Milk Butyrophilin shares a similar homology to myelin and has been shown to degrade myelin tissues through molecular mimicry and cross-reactivity. Patients exhibiting neurological disorders should therefore abstain from consuming milk products.
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