M007-IgG Botrytis cinerea

Serum
Optimal Result: 0 - 1.9 ug/ml.

Botrytis cinerea is called the grey mold, as it covers the decayed tissues with conidiophores.

B. cinerea is found regularly in the soil, though its proportion of the total fungus population is not high. It can be parasitic on a wide range of plants, causing blight or rot of leaves, flowers and fruits. It is called the grey mold, as it covers the decayed tissues with conidiophores, e.g. grey mold of cabbage or lettuce, tomato. It is especially seen in connection with soft fruits, e.g. strawberries and grapes.

Individuals exposed to B. cinerea may be sensitised to this fungus without experiencing any clinical symptoms, or may experience exacerbation of symptoms of asthma, hayfever or sinusitis, or may develop hypersensitivity pneumonitis (also known as 'winegrower's lung'). IgE- binding components from B. cinerea appear to have both early- and late-phase antigens.

Botrytis cinerea is a ubiquitous, necrotrophic, phytopathic fungus. It poses a significant economic burden worldwide through spoilage of various crops pre-and post-harvest. B. cinerea has a low prevalence in both outdoor and indoor environments, despite there being a high prevalence of sensitization. B. cinerea causes allergic rhinitis in children and adults, asthma in children and hypersensitivity pneumonitis in the horticultural and viticultural settings. There is currently no recognized B. cinerea allergen.

The indoor prevalence of B. cinerea in damp-free households is estimated between 0–4.8%, and prevalence in damp homes ranges between 0.9–5.5%, with a calculated median of 2%. This is higher than the calculated median for damp-free indoor and environments (1.1%), providing evidence of increased Botrytis levels in damp homes (7).

 

What does it mean if your M007-IgG Botrytis cinerea result is too high?

There are no B. cinerea-specific allergens recognized by the WHO IUIS Allergen Nomenclature Sub-committee.

It has been proposed that, in common with other fungi, the cell wall carbohydrates of B. cinerea may play a role in the pathogenesis of allergic airway disease. Fungal b-glucans promote allergic sensitization to co-administered antigens in the lung. A study in a murine model has shown that co-exposure of a high molecular weight allergen with Avicularia versicolor spores results in a more severe asthma phenotype. Furthermore, the immune response was altered by the presence of fungus, with enhanced Th2 cell response and an additional Th17 response. Chitin could also play a role, with high chitin expressing fungal isolates eliciting increased airway eosinophilia.

B. cinerea is found regularly in the soil, though its proportion of the total fungus population is not high. It can be parasitic on a wide range of plants, causing blight or rot of leaves, flowers and fruits. It is called the grey mold, as it covers the decayed tissues with conidiophores, e.g. grey mold of cabbage or lettuce, tomato. It is especially seen in connection with soft fruits, e.g. strawberries and grapes.

Individuals exposed to B. cinerea may be sensitised to this fungus without experiencing any clinical symptoms, or may experience exacerbation of symptoms of asthma, hayfever or sinusitis, or may develop hypersensitivity pneumonitis (also known as 'winegrower's lung'). 

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