Lipopolysaccharide Antibody

Stool
check icon Optimal Result: 0 - 10 Units.

Lipopolysaccharides (LPS) are inflammatory endotoxins released from the outer cell walls of gram-negative bacteria in the gastrointestinal tract. Under healthy conditions, the gut lining acts as a barrier that prevents significant amounts of LPS from entering the bloodstream. When this barrier becomes compromised—due to dysbiosis, infections, stress, medications, or inflammation—LPS can cross into circulation and trigger an immune response.

The Lipopolysaccharide Antibody marker reflects the body’s adaptive immune reaction to repeated or sustained exposure to these endotoxins. Elevated antibody levels suggest ongoing immune recognition of LPS, which is commonly associated with increased gut permeability, chronic inflammation, and microbial imbalance.

Persistently high LPS antibody levels have been linked in research to systemic inflammation, metabolic dysfunction, insulin resistance, autoimmune activation, and neuroinflammatory symptoms. In the context of the Gut Zoomer panel, this marker is particularly useful for identifying immune-driven gut barrier dysfunction that may not be evident from microbial abundance data alone.

Interpretation should always consider related Gut Zoomer findings such as zonulin markers, bacterial overgrowth patterns, inflammatory markers, and clinical symptoms.

Result Interpretation

Optimal Range: 0.1 – 10

Results in this range suggest minimal immune activation against bacterial endotoxins. This is consistent with an intact gut barrier, balanced microbial ecology, and controlled immune signaling.

Moderate Range: 10 – 20

Values in this range indicate early or moderate immune reactivity to LPS. This may reflect developing gut permeability, mild dysbiosis, recent infections, dietary triggers, or transient inflammatory stress. Clinical symptoms may or may not yet be present.

High / Critical Range: 20+

Results above 20 indicate significant immune activation in response to endotoxin exposure. This strongly suggests increased intestinal permeability and chronic exposure to gram-negative bacterial toxins. High levels are commonly associated with systemic inflammation, fatigue, brain fog, joint pain, metabolic issues, and autoimmune flares.

What does it mean if your Lipopolysaccharide Antibody result is too high?

High LPS antibody levels suggest chronic immune stimulation from gut-derived endotoxins, often driven by leaky gut, dysbiosis, or persistent inflammatory stress. Targeted gut-healing, microbiome support, and inflammation-reducing interventions are commonly considered in response to elevated results.

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