Serum soluble interleukin-2 receptor (sIL-2R) is considered a marker of lymphocyte (T and B cell)-mediated immune activation, and elevated levels have been recognised as a biomarker for malignant lymphoma, such as non-Hodgkin’s lymphoma and adult T-cell leukaemia/lymphoma. Serum sIL-2R levels are commonly measured to evaluate the disease state and therapeutic effect, and to detect recurrence in patients with malignant lymphoma in daily practice.
References:
Murakami, Jun et al. “Serum soluble interleukin-2 receptor levels for screening for malignant lymphomas and differential diagnosis from other conditions.” Molecular and clinical oncology vol. 11,5 (2019): 474-482. doi:10.3892/mco.2019.1922
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- Increased levels of the soluble IL-2Rα in biological fluids correlate with activation of T and/or B cells.
- The serum soluble interleukin 2 receptor (sIL2R) level is elevated in patients with most types of lymphoid neoplasms, and is also elevated in patients with solid tumors or reactive conditions, such as severe inflammation. [L]
- Results of a number of studies suggest a correlation of levels of IL-2Rα in serum with disease activity in autoimmune and infectious disorders as well as in transplantation rejection.
- Markedly increased IL-2sRα levels have been associated with hematologic malignancies.
- Levels of IL-2Rα correlate with tumor burden and response to therapy in numerous malignancies.
- IL-2Rα levels can be used to predict the long-term prognosis in non-Hodgkin lymphoma patients and to assess the status of patients with HIV and acquired immunodeficiency.
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