Cytokine Panel 13, Serum

Interleukin 2 Receptor, Soluble, Serum

Other names: Soluble IL 2R

Optimal result: 175.3 – 858.2 pg/mL

Quest Diagnostics

By Healthmatters Editorial Team

Peer-reviewed sources

- Increased levels of the soluble IL-2Rα in biological fluids correlate with activation of T and/or B cells.

- The serum soluble interleukin 2 receptor (sIL2R) level is elevated in patients with most types of lymphoid neoplasms, and is also elevated in patients with solid tumors or reactive conditions, such as severe inflammation. [L]

- Results of a number of studies suggest a correlation of levels of IL-2Rα in serum with disease activity in autoimmune and infectious disorders as well as in transplantation rejection.

- Markedly increased IL-2sRα levels have been associated with hematologic malignancies.

- Levels of IL-2Rα correlate with tumor burden and response to therapy in numerous malignancies.

- IL-2Rα levels can be used to predict the long-term prognosis in non-Hodgkin lymphoma patients and to assess the status of patients with HIV and acquired immunodeficiency.

Soluble Interleukin 2 receptor concentration reflects the immune activation in autoimmune diseases, neoplasms (notably lymphoproliferations), and infections.

Serum soluble interleukin-2 receptor (sIL-2R) is considered a marker of lymphocyte (T and B cell)-mediated immune activation, and elevated levels have been recognised as a biomarker for malignant lymphoma, such as non-Hodgkin’s lymphoma and adult T-cell leukaemia/lymphoma. Serum sIL-2R levels are commonly measured to evaluate the disease state and therapeutic effect, and to detect recurrence in patients with malignant lymphoma in daily practice.

References:

Murakami, Jun et al. “Serum soluble interleukin-2 receptor levels for screening for malignant lymphomas and differential diagnosis from other conditions.” Molecular and clinical oncology vol. 11,5 (2019): 474-482. doi:10.3892/mco.2019.1922

Rubin LA, Nelson DL. The soluble interleukin-2 receptor: biology, function, and clinical application. Ann Intern Med. 1990 Oct 15;113(8):619-27. doi: 10.7326/0003-4819-113-8-619. PMID: 2205142.

N Yasuda, PK Lai, SH Ip, PC Kung, Y Hinuma, M Matsuoka, T Hattori, K Takatsuki, DT Purtilo; Soluble interleukin 2 receptors in sera of Japanese patients with adult T cell leukemia mark activity of disease. Blood 1988; 71 (4): 1021–1026. doi: https://doi.org/10.1182/blood.V71.4.1021.1021

Wagner DK, Kiwanuka J, Edwards BK, Rubin LA, Nelson DL, Magrath IT. Soluble interleukin-2 receptor levels in patients with undifferentiated and lymphoblastic lymphomas: correlation with survival. J Clin Oncol. 1987 Aug;5(8):1262-74. doi: 10.1200/JCO.1987.5.8.1262. PMID: 3114436.

Chrobák L. Clinical significance of soluble interleukin-2 receptor. Acta Medica (Hradec Kralove). 1996;39(1):3-6 (review). PubMed 9106384

Zerler B. The soluble interleukin-2 receptor as a marker for human neoplasia and immune status. Cancer Cells. 1991 Dec;3(12):471-479. PubMed 1820093

Bodey B, Psenko V, Lipsey AL, Kaiser HE. Soluble interleukin-2 receptors in sera of children with primary malignant neoplasms. Anticancer Res. 1996 Jan-Feb;16(1):219-224. PubMed 8615612

Wagstaff J, Baars JW, Wolbink GJ, Hoekman K, Eerenberg-Belmer AJ, Hack CE. Renal cell carcinoma and interleukin-2: A review. Eur J Cancer. 1995;31A(3):401-408 (review). PubMed 7540404

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