Holdemania is a genus of Gram-positive, anaerobic bacteria that resides primarily in the large intestine as part of the normal human gut microbiome. While not as well studied as some major bacterial groups, Holdemania is increasingly recognized as a supportive commensal organism associated with gut ecosystem balance and metabolic health.
In a healthy gut, Holdemania contributes to overall microbial diversity and participates indirectly in metabolic and immune signaling pathways. Adequate diversity is critical for maintaining gut barrier integrity, regulating inflammation, and supporting efficient nutrient metabolism.
Low Holdemania levels are more commonly noted on comprehensive stool testing and may reflect reduced microbial diversity, prior antibiotic exposure, chronic inflammation, or a depleted gut environment. This pattern can be associated with digestive symptoms, metabolic imbalance, or reduced resilience of the microbiome under stress.
Elevated Holdemania levels are less frequently emphasized but may indicate compensatory microbial shifts or early dysbiosis, particularly if seen alongside other imbalanced anaerobic bacteria. Interpretation depends on the broader microbiome context rather than this marker alone.
On the Gut Zoomer panel, Holdemania is evaluated as part of a systems-based view of gut health, helping practitioners assess whether the microbiome shows signs of balance, depletion, or adaptive shifts in response to inflammation or metabolic stress.
What does it mean if your Holdemania result is too high?
Elevated Holdemania levels may reflect microbial imbalance or compensatory shifts within the gut ecosystem. High values are interpreted in context and may be associated with dysbiosis or altered metabolic signaling when accompanied by other abnormal microbiome or inflammatory markers.
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