Hafnia is a genus of Gram-negative, facultative anaerobic bacteria found in various environments, including the human gastrointestinal tract. Within the gut microbiome, Hafnia is thought to contribute to microbial balance, immune modulation, and metabolic regulation, making it a potentially meaningful biomarker of overall gut health.
On the Gut Zoomer panel, Hafnia is evaluated as part of a broader microbiome and functional gut assessment rather than as a classic pathogen. Its clinical relevance lies in how its abundance reflects the stability and resilience of the gut ecosystem.
Low Hafnia levels, particularly below the expected reference threshold (commonly reported as >10), may indicate reduced microbial diversity, impaired microbiota balance, or loss of beneficial microbial functions. This can be seen in individuals with chronic gut dysfunction, inflammatory conditions, metabolic disturbances, or after antibiotic exposure.
Elevated Hafnia levels, while less commonly emphasized, may still reflect dysbiosis or shifts toward opportunistic bacterial dominance, especially if accompanied by inflammatory markers or other imbalanced Enterobacteriaceae species.
Because Hafnia has been linked to immune responses and metabolic processes, abnormal levels may help explain connections between digestive symptoms and broader systemic issues such as immune stress, low-grade inflammation, or metabolic imbalance.
On the Gut Zoomer, Hafnia is interpreted in context with microbial diversity, inflammatory markers, gut barrier integrity, and digestive function to determine whether it reflects a loss of balance, compensatory microbial shifts, or broader ecosystem disruption.
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What does it mean if your Hafnia result is too low?
Low Hafnia levels may indicate reduced gut microbiome resilience, diminished microbial diversity, or impaired support for immune and metabolic signaling. When combined with other low commensal organisms, this pattern may reflect a weakened or depleted gut ecosystem.
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