This test looks for autoantibodies that target ganglionic nicotinic acetylcholine receptors (α3-AChR)—key “signal docks” inside the autonomic nervous system, which controls involuntary functions like blood pressure, heart rate, sweating, digestion, and bladder function.
If your immune system makes these antibodies, it can disrupt autonomic signaling and cause dysautonomia. The most specific condition is Autoimmune Autonomic Ganglionopathy (AAG).
Your clinician may order this test if you have unexplained autonomic symptoms, such as:
Orthostatic hypotension (lightheadedness or fainting when standing)
Dry mouth / dry eyes
Abnormal sweating (too much or too little)
Digestive issues (constipation, nausea, bloating, early fullness)
Bladder problems (retention, urgency, incontinence)
Pupil abnormalities (light sensitivity, blurry vision)
Erectile dysfunction or heart-rate/blood-pressure instability
It’s also used when clinicians suspect paraneoplastic (cancer-related) neurologic disease—most often with small cell lung cancer or thymoma.
Ranges vary by lab. Common interpretations:
Negative: < 0.02 nmol/L
Borderline / Indeterminate: 0.02–0.05 nmol/L
Positive: > 0.05 nmol/L
High positive (often more specific for AAG): > 0.20 nmol/L
Always interpret your exact value using the reference interval on your report.
What it suggests:
Supports an autoimmune cause of dysautonomia, most notably AAG.
Higher titers often track with more severe or widespread autonomic involvement, though exceptions exist.
What to do next:
Share the result with your clinician. They may recommend:
Autonomic function testing (tilt-table, QSART/sweat testing, heart-rate variability)
Targeted cancer screening (e.g., CT chest, PET/CT, or other imaging) to rule out paraneoplastic causes
Expanded autoantibody panels (paraneoplastic/neuronal antibodies)
Discuss immunotherapy options where appropriate: IVIG, plasma exchange, corticosteroids, or steroid-sparing agents (e.g., rituximab, mycophenolate, azathioprine).
Symptom-focused care for blood pressure, GI motility, bladder function, and temperature/sweating can improve daily life.
Practical tips while you wait for care:
For orthostatic symptoms: rise slowly, hydrate well, consider compression stockings, and ask about salt/fluid strategies if safe for you.
Track blood pressure and symptom patterns to share with your clinician.
What it suggests:
Low-level positivity can occur with limited or early disease, other autoimmune conditions, or occasionally without clear disease.
What to do next:
Correlate with symptoms and autonomic testing.
Your clinician may repeat the test or add related antibody panels.
Continue evaluation for common non-autoimmune causes of similar symptoms (medications, dehydration, diabetes, Parkinsonian syndromes, etc.).
What it suggests:
Makes antibody-mediated AAG less likely, but does not fully exclude it. A minority of patients can be seronegative.
Think broadly: medication side effects, volume depletion, neuropathies (e.g., diabetes), POTS, neurodegenerative conditions.
What to do next:
If symptoms persist or are severe, ask about autonomic function testing, alternative antibodies, and evaluation for other causes of dysautonomia.
Autonomic reflex screen (tilt-table, QSART, heart-rate variability to deep breathing/Valsalva)
Paraneoplastic antibody panel (e.g., anti-Hu/ANNA-1, CRMP-5, etc.)
Cancer screening when clinically indicated (CT chest, PET/CT, mammography, colonoscopy, based on age/risk)
Basic labs to rule out mimics: CBC, CMP, fasting glucose/HbA1c, B12, TSH, SPEP, autoimmune panels
Autoimmune Autonomic Ganglionopathy (AAG)
Paraneoplastic autonomic neuropathy (notably small cell lung carcinoma)
Thymoma-associated autoimmunity
Occasionally seen with other systemic autoimmune diseases
Many patients benefit from immunotherapy (IVIG, plasma exchange, corticosteroids; selected cases: rituximab or other immunosuppressants).
Symptom-targeted therapies (midodrine, droxidopa, fludrocortisone for orthostatic hypotension; pro-motility agents for GI symptoms; bladder protocols) improve quality of life.
Monitoring titers over time can help some clinicians track disease activity, but symptom changes and autonomic testing usually guide treatment decisions.
Some patients recover partially or fully; others may have a chronic or relapsing course.
Is a high titer always severe disease?
No. Higher levels often correlate with severity, but not perfectly. Clinical evaluation remains essential.
Can I have AAG with a negative test?
Yes—seronegative AAG exists. Diagnosis relies on symptoms + autonomic testing, not the antibody alone.
Should everyone with a positive test get cancer screening?
Your clinician will tailor screening to your age, risks, and symptoms, but a thoughtful search is common with positive results, especially at higher titers.
How fast do treatments work?
Response varies by therapy and disease severity. Some patients notice improvement within weeks, others months. Ongoing follow-up is important.
Match the number to your lab’s reference range.
Document your symptoms (when they start, what triggers/worsens them).
Share the result with your healthcare provider and discuss next steps (testing, screening, treatment).
Track progress: blood pressure logs, hydration, and symptom diaries can guide care.
Seek urgent care for fainting with injury, chest pain, severe dehydration, or sudden neurologic changes.
A high Ganglionic Acetylcholine Receptor Antibody (Ganglionic AChRAb) suggests an autoimmune cause of dysautonomia, most specifically Autoimmune Autonomic Ganglionopathy (AAG) or a paraneoplastic autonomic neuropathy. Titer (how high the number is) can correlate with severity, but clinical context is essential.
Positive (> your lab’s cutoff, often >0.05 nmol/L): Supports an immune attack on ganglionic nicotinic AChR (α3) in autonomic ganglia.
Higher-positive (e.g., >0.20 nmol/L): More strongly associated with AAG and moderate–severe autonomic failure, though exceptions occur.
Borderline/low-positive: May indicate early/limited disease or overlap with other autoimmune conditions; repeat testing and clinical correlation are key.
Always interpret using the reference range printed on your report, as cutoffs vary by lab.
Autoimmune Autonomic Ganglionopathy (AAG) – primary association.
Paraneoplastic autonomic neuropathy – most often linked to small cell lung carcinoma (SCLC); also reported with thymoma and some other malignancies.
Other autoimmunity – occasionally seen with systemic autoimmune diseases (context-dependent).
Cardiovascular: orthostatic hypotension (dizziness/fainting on standing), heart-rate variability.
Sweat/temperature: too little or too much sweating, heat intolerance.
Gastrointestinal: constipation, early satiety, nausea, bloating.
Genitourinary: urinary retention, urgency, incontinence; erectile dysfunction.
Eyes/pupils: light sensitivity, blurry vision.
Serology ≠ diagnosis: Some patients with classic AAG are seronegative, and some with low-positive results may have limited disease.
Medications and mimics: Dehydration, diabetes neuropathy, Parkinsonian syndromes, medication side effects, and POTS can produce overlapping symptoms and should be reviewed.
Trend, not just a point: Serial measurements may help track disease activity in context with symptoms and formal autonomic testing.
Share the result with your clinician and review your full symptom history (include blood pressure/symptom logs).
Autonomic testing: Tilt-table, QSART/sudomotor testing, heart-rate variability (deep breathing/Valsalva), pupillometry where available.
Targeted cancer evaluation if clinically appropriate (especially with higher titers or red flags): CT chest, PET/CT, age-appropriate screenings.
Extended antibody panels: Paraneoplastic and neuronal antibodies (e.g., anti-Hu/ANNA-1, CRMP-5) when suspicion is higher.
Manage complications now:
Orthostatic hypotension: fluid/salt strategies if safe, compression garments, head-of-bed elevation; discuss fludrocortisone, midodrine, or droxidopa with your clinician.
GI dysmotility: nutrition/hydration planning; prokinetics as appropriate.
Bladder dysfunction: timed voids, urology referral if needed.
Immunotherapy: IVIG, plasma exchange, corticosteroids; in selected cases rituximab or other steroid-sparing agents.
Symptom-directed care: BP support agents, GI motility treatments, bladder protocols, temperature/sweat management.
Monitoring: Symptom diaries + periodic autonomic testing; consider repeating antibody titers per clinician guidance.
Does my titer level change the urgency or type of evaluation?
Which autonomic tests are most informative for my symptoms?
Do I need cancer screening now? If so, which studies?
Which immunotherapy is most appropriate for my situation, and how will we measure response?
What at-home strategies can reduce fainting risk and GI/bladder symptoms?
Recurrent fainting with injury, chest pain, signs of severe dehydration, or sudden, rapidly worsening neurologic symptoms.
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Our user-friendly form guides you through a quick, simple submission process, making it easy to enter your health metrics.
Add your results anytime with our easy entry form. It's quick, guided, and helps you stay organized — free for all members.
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See your lab reports in clear graphs and tables. Spot patterns, track changes, and compare results over time — all in one place.
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Export Your Complete Lab History
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After collecting lab results from different providers, you can download your entire history combined into a single file.
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Data Entry Service for Your Reports
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest. Complete plan members receive one report entered for free, then $15 per report after that. Unlimited plan members receive ten report entries for free, then $15 per report after that.
Our inclusive service handles the data entry for your lab reports. Just submit your information and we'll take care of the rest.
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Whether you're working with a doctor, nutritionist, caregiver, or wellness coach, you can securely share your complete lab history by sending an invite link to anyone you trust. You have full control over who sees your information and for how long, ensuring your privacy and peace of mind at every step.
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I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
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As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
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Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
If you're on the hunt for a specific biomarker, contact us and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account.
The Complete Plan ($15/month) is perfect for individuals who want ongoing access to their health data. It includes unlimited lab imports, visual tracking, custom ranges, result explanations, full account exports, and secure sharing — all with a simple monthly subscription. You can cancel anytime and restart your plan whenever you're ready — your data will still be there waiting for you. You can also upgrade to the Unlimited Plan at any time, with the cost prorated based on what you've already paid.
The Unlimited Plan ($250 one-time) is also designed for individuals but offers lifetime access with no ongoing subscription. You'll get all the same features as the Complete Plan, plus a larger initial data entry allowance (10 reports), making it a great choice if you prefer a one-time payment and long-term use without monthly fees.
In short:
There are two ways to add your test reports to your Healthmatters account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you.
We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our Data Entry Service is for when you don't want to manually type in your lab results yourself. You simply upload your report (PDF, image, or screenshot), and our trained team enters the information into your Healthmatters account for you — accurately and neatly organized, ready to view in graphs, tables, and timelines.
The $15 per report covers the time and care it takes for a real person to review your file, make sure each result is entered correctly, and double-check for accuracy. This ensures your health data is precise and easy to work with — without you having to spend the time doing it yourself.
Prefer to do it yourself? You can always use our free self-entry tool to add results manually — it just takes a bit more time and attention.
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All professional accounts allow you to import and onboard an unlimited number of clients and their lab results. The distinction between professional plans lies solely in the data entry service.
The Pro Monthly Plus plan is priced at $75 per month and includes a data entry service for five reports each month. Additional reports can be self-entered at no extra cost or, if preferred, you can use our data entry service for an additional fee of $15 per report.
The Pro Monthly plan is priced at $45 per month and does not include a data entry service. Self-entry is free for an unlimited number of reports, and you can opt for the data entry service at a fee of $15 per report.
You also have the option to upgrade to higher monthly or to annual plans, which come with substantial discounts. All upgrades can be done directly from your account.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
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We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
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Yes, you can download your information anytime. We offer two easy ways to export your lab data:
This makes it simple to save, back up, or share your health data whenever you need.
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Yes, you can! We highly recommend activating Two-Factor Authentication (2FA) for your account. To do so, please navigate to the "Profile and Security" section of your account, where you will find instructions for activating 2FA.
Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
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Optimal Result:
0 - 0.07 nmol/L.