Optimal Result:
0 - 0.03 mg/kg Dry Wt.
Fecal gadolinium (Gd) provides an indication of Gd that has been excreted from the body in bile, and to a lesser extent oral exposure. Gadolinium can be found in the environment in geographically variable amounts, and usually at very low levels. Gadolinium is widely used in industrial and household applications such as radar technologies, compact discs, and microwaves; direct exposure from such sources is not a concern. However disposal of Gd-containing devices contributes to greater potential for human exposure.
The single greatest direct source of exposure to Gd is Gd-based contrast agents (GBCAs) that are widely used with magnetic resonance imaging (MRI). Concern has been raised regarding the use of unstable linear GBCAs, especially for patients with mild to severe kidney dysfunction. Fecal Gd levels vary with the time after administration, and the dose of the specific GBCA. There is much controversy regarding the safety of certain unstable GBCAs; Gd doesn’t have physiological functions in the body.
Urinary levels of Gd typically decrease very rapidly after administration for patients who have good kidney function (glomerular filtration rate; GFR). However, the rate of Gd clearance may be markedly slowed with compromised GFR. Fecal Gd levels have not been well studied, but preliminary observations indicate that fecal levels of Gd also normally decrease sharply with time after administration of GBCAs (unpublished, Doctor’s Data). While the Gd levels normally decrease rather rapidly in urine and feces, it is clear that some Gd is retained in the body for a long time. Of greatest potential concern is Gd deposition in the brain, which is correlated with the number of GBCA-enhanced MRIs. Gadolinium deposition disease (GDD) has recently been described and may be associated with central
and peripheral pain, headache, bone pain, skin thickening, muscle weakness, arthralgia, and persistent clouded mentation and headache. If such new symptoms appear 2-8 weeks after Gd-enhanced MRI, it is recommended to assess the level of Gd in urine (1st AM void or 24 hour collection).
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What does it mean if your Gadolinium result is too high?
The single greatest direct source of exposure to Gd is Gd-based contrast agents (GBCAs) that are widely used with magnetic resonance imaging (MRI). Concern has been raised regarding the use of unstable linear GBCAs, especially for patients with mild to severe kidney dysfunction. Fecal Gd levels vary with the time after administration, and the dose of the specific GBCA. There is much controversy regarding the safety of certain unstable GBCAs; Gd doesn’t have physiological functions in the body.
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