Fibrosis Stage estimates how much scarring (fibrosis) is present in your liver by converting a FibroTest® score (f)—a composite of routine blood markers plus age/sex—into the familiar METAVIR staging system (F0–F4). It’s used to triage risk, decide on next tests (e.g., FibroScan®/elastography), guide treatment intensity, and monitor change over time, often without needing a biopsy.
How to read your result
Your FibroTest score (f) falls into one of the ranges below, which map to a METAVIR stage. “Bridged” categories (e.g., F1–F2) indicate an intermediate probability between two adjacent stages.
FibroTest (f) → METAVIR stage
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f ≥ 0.00 and f ≤ 0.21: F0 (no fibrosis)
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f > 0.21 and f ≤ 0.27: F0–F1 (no fibrosis)
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f > 0.27 and f ≤ 0.31: F1 (minimal fibrosis)
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f > 0.31 and f ≤ 0.48: F1–F2 (minimal fibrosis)
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f > 0.48 and f ≤ 0.58: F2 (moderate fibrosis)
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f > 0.58 and f ≤ 0.72: F3 (advanced fibrosis)
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f > 0.72 and f ≤ 0.74: F3–F4 (advanced fibrosis)
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f > 0.74 and f ≤ 1.00: F4 (severe fibrosis / cirrhosis)
Always interpret your number using the reference printed on your report and in clinical context.
What each stage generally means
F0 (no fibrosis)
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What it means: No measurable scarring. Liver architecture is preserved.
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Typical next steps: Maintain liver-healthy habits; periodic reassessment based on risk (e.g., 1–3 years).
F0–F1 (no fibrosis) and F1 (minimal fibrosis)
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What it means: Little to no scarring (F0–F1) or early/minimal scarring (F1).
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Implications: Excellent outlook if risk factors are addressed.
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Follow-up: Lifestyle optimization; treat the cause (e.g., viral hepatitis therapy, alcohol cessation, metabolic care). Re-check at intervals set by your clinician.
F1–F2 (minimal → moderate fibrosis)
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What it means: Transition zone—some patients behave like F1, others like F2.
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Implications: Rising risk of progression if the underlying disease persists.
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Follow-up: Consider confirmatory testing (e.g., FibroScan®), closer monitoring, and proactive treatment of the cause.
F2 (moderate fibrosis)
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What it means: Clinically meaningful scarring; progression risk is higher.
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Implications: Intensify management of the underlying condition (MASLD/NASH, viral hepatitis, alcohol-related, etc.).
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Follow-up: Non-invasive fibrosis assessment and labs at regular intervals; consider hepatology referral.
F3 (advanced fibrosis) and F3–F4 (advanced → severe)
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What it means: Extensive scarring with architectural distortion; one step from cirrhosis (F4).
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Implications: Elevated risk for complications; requires specialist involvement.
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Follow-up: Confirm with elastography/imaging; manage portal hypertension risks; aggressive cause-directed therapy.
F4 (severe fibrosis / cirrhosis)
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What it means: Cirrhosis—extensive scarring and nodule formation.
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Implications: Assess for decompensation risks and hepatocellular carcinoma (HCC) surveillance per guidelines.
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Follow-up: Ongoing hepatology care, vaccination review (HAV/HBV if non-immune), nutrition support, and complication screening.
When scores may be misleading
Certain factors can artificially raise or lower components of the FibroTest and shift the stage:
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Acute hepatitis or recent flare (spikes AST/ALT, bilirubin)
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Cholestasis, Gilbert syndrome, hemolysis
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Severe inflammation or intercurrent illness
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Recent heavy alcohol use
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Medications/supplements affecting liver enzymes or lipids
If any apply, clinicians often repeat testing after stabilization or confirm with elastography.
What you can do (at any stage)
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Treat the cause: antiviral therapy for HBV/HCV when indicated; alcohol cessation; structured care for MASLD/NASH (weight loss target 7–10% if overweight/obese; diabetes control; lipid management).
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Lifestyle: Mediterranean-style eating pattern; limit fructose-sweetened beverages and ultra-processed foods; regular aerobic + resistance exercise; sleep and stress management.
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Risk reduction: Vaccinate (HAV/HBV if non-immune), review meds for hepatotoxicity, manage cardiovascular and renal risks.
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Monitoring: Follow your personalized schedule for labs and non-invasive fibrosis tests; escalate assessment if results worsen or symptoms change.
Key takeaways
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Your FibroTest score maps to METAVIR to communicate fibrosis severity from F0 (none) to F4 (cirrhosis).
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Border zones (F0–F1, F1–F2, F3–F4) reflect intermediate probabilities—often prompting confirmatory elastography.
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Use the stage to guide action: maintain liver health at low stages; intensify treatment and monitoring at moderate/advanced stages; engage hepatology at F3–F4.
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Results work best in context—paired with clinical history, imaging, and follow-up over time.
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