Ethylmalonate
Other names: can give information about your ability to process fatty acids
Ethylmalonate, together with Adipate and Suberate, gives information about your ability to process fatty acids.
Ethylmalonate, which comes from the breakdown of butyrate, has a carnitine-dependent pathway and can accumulate with an insufficient amount of carnitine. Dietary fat, carbohydrate, and protein are all broken down to produce energy using pathways that require vitamin B2 (riboflavin).
If you do not have sufficient riboflavin, compounds such as adipate, suberate, and ethylmalonate may increase in urine.
What is Carnitine?
Carnitine helps your body use fatty acids. The body makes small amounts of carnitine.
However, if minimum requirements are not met, carnitine dependent functions fail to proceed normally. Long-chain fatty acids go through beta-oxidation in the mitochondria, which is a carnitine dependent step.
If there are inadequate amounts of carnitine, the long-chain fatty acids will get processed outside of the mitochondria; Adipate and suberate are by-products of long-chain fatty acid breakdown outside of the mitochondria.
What does it mean if your Ethylmalonate result is too high?
High levels of ethylmalonate may occur when there are nutritional enzyme inhibitions of the breakdown pathways, inherited low-activity enzymes are present, if there are high levels of precursors (adipate, suberate, isoleucine), or if there are higher levels of its downstream products (methylsuccinate). Ethylmalonate can increase if liver beta-oxidation of fatty acids is impaired. Obesity may increase levels, and high levels may also occur if the patient is on a high-fat or -protein diet or using methionine or branch-chain amino acid supplements. Mobilization of stored body fat during fasting or calorie restriction may also increase ethylmalonate levels. Ethylmalonate can also be synthesized by bacteria in the gut microbiome, and levels may increase if there is gut dysbiosis.
- Low-activity enzyme variants may benefit from a lower protein diet. Consider supporting ethylmalonate breakdown pathways with adenosylcobalamin (B12), biotin, L-carnitine and magnesium. If using methionine loading or a high-protein diet consider B6, molybdenum and N-acetyl-cysteine supplementation in addition. If using branch-chain amino acid supplements consider vitamins B1, B2, B3, B6 and lipoic acid to support breakdown. Methylsuccinate levels may be low with B12 deficiency, but ethylmalonate and methylmalonate may be high. Methylmalonate is derived primarily from the amino acid valine. If alpha-ketoisovalerate is high, there may be a downstream block that prevents the formation of methylmalonate, and levels may be lower than expected even if there is a vitamin B-12 deficiency present.
- Consider supporting liver beta-oxidation with vitamins B2, B3, iron (if deficient), sulforaphane and resveratrol.
- Review the Markers of Bacterial Metabolism for clues about dysbiosis. Evaluate and correct dysbiosis when appropriate.
- Phthalate exposures can inhibit beta-oxidation and increase levels of adipate, suberate, ethylmalonate, and methylsuccinate. Consider US BIOTEK’S ENVIRONMENTAL POLLUTANTS PROFILE to assess phthalate exposure.
All Your Lab Results.
One Simple Dashboard.
Import, Track, and Share Your Lab Results Easily
Import, Track, and Share Your Lab Results
Import lab results from multiple providers, track changes over time, customize your reference ranges, and get clear explanations for each result. Everything is stored securely, exportable in one organized file, and shareable with your doctor—or anyone you choose.
Cancel or upgrade anytime
What does it mean if your Ethylmalonate result is too low?
Low levels of ethylmalonate may occur if there are low levels of precursors (adipate, suberate, isoleucine), if there are nutritional enzyme inhibitions, or if a low-activity enzyme variant is inherited. Ethylmalonate, like methylsuccinate, is primarily derived from branched-chain fatty acids (beef, dairy, miso, sauerkraut). Patients on a low-fat diet or with fat malabsorption may have lower ethylmalonate levels. Ethylmalonate is the precursor for methylsuccinate, which is taken up by pancreatic beta-cells.
Consider supporting synthesis with vitamins B2, B3, biotin, magnesium and L-carnitine.
Laboratories
Bring All Your Lab Results Together — In One Place
We accept reports from any lab, so you can easily collect and organize all your health information in one secure spot.
Pricing Table
Gather Your Lab History — and Finally Make Sense of It
Finally, Your Lab Results Organized and Clear
Personal plans
$79/ year
Advanced Plan
Access your lab reports, explanations, and tracking tools.
- Import lab results from any provider
- Track all results with visual tools
- Customize your reference ranges
- Export your full lab history anytime
- Share results securely with anyone
- Receive 5 reports entered for you
- Cancel or upgrade anytime
$250/ once
Unlimited Account
Pay once, access everything—no monthly fees, no limits.
- Import lab results from any provider
- Track all results with visual tools
- Customize your reference ranges
- Export your full lab history anytime
- Share results securely with anyone
- Receive 10 reports entered for you
- No subscriptions. No extra fees.
$45/ month
Pro Monthly
Designed for professionals managing their clients' lab reports
- Import lab results from any provider
- Track lab results for multiple clients
- Customize reference ranges per client
- Export lab histories and reports
- Begin with first report entered by us
- Cancel or upgrade anytime
About membership
What's included in a Healthmatters membership
Import Lab Results from Any Source
See Your Health Timeline
Understand What Your Results Mean
Visualize Your Results
Data Entry Service for Your Reports
Securely Share With Anyone You Trust
Let Your Lab Results Tell the Full Story
Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.
Bring all your results together to compare, track progress, export your history, and share securely.
What Healthmatters Members Are Saying
Frequently asked questions
Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
- Individuals who want to track and understand their health over time.
- Health professionals, such as doctors, nutritionists, and wellness coaches, need to manage and interpret lab data for their clients.
With a Healthmatters account, you can:
- Upload lab reports from any lab
- View your data in interactive graphs, tables, and timelines
- Track trends and monitor changes over time
- Customize your reference ranges
- Export and share your full lab history
- Access your results anytime, from any device
Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 10000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
- The GI Effects® Comprehensive Stool Profile,
- GI-MAP,
- The NutrEval FMV®,
- The ION Profile,
- Amino Acids Profile,
- Dried Urine Test for Comprehensive Hormones (DUTCH),
- Organic Acids Test,
- Organix Comprehensive Profile,
- Toxic Metals,
- Complete Blood Count (CBC),
- Metabolic panel,
- Thyroid panel,
- Lipid Panel,
- Urinalysis,
- And many, many more.
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
We implement proven measures to keep your data safe.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.