Diacetoxyscirpenol (DAS), also known as anguidine, is a type A trichothecene mycotoxin primarily produced by Fusarium fungi. Trichothecenes are known as major contaminants of cereals and cereal-containing foods. DAS has been detected in agricultural products worldwide and persists in products after processing. In human as well as in animals, DAS consumption has been shown to induce haematological disorders (neutropenia, aplastic anemia). In the published literature, DAS has mainly been reported in various cereal grains (principally wheat, sorghum, maize, barley and oats) and cereal products, but also in potato products, soybeans and coffee. The highest levels have been reported for wheat, sorghum and coffee. DAS has been found to co-occur with many other mycotoxins in grains and grain-based products, in particular Fusarium toxins including type A and B trichothecenes, and zearalenone.
References:
- Pestka, J., Toxicological mechanisms and potential health effects of deoxynivalenol and nivalenol. World Mycotoxin Journal 2010, 3 (4), 323-347.
Diacetoxyscirpenol (DAS)
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