CaM Kinase II (CaMKII), % of Baseline
Other names: Ca/Calmodulin Protein Kinase II (% of baseline), Calcium/calmodulin-dependent protein kinase II (CaMKII) Cell-Stimulation Assay
CaM Kinase II (CaMKII) is a critical enzyme involved in many essential brain functions, including neurotransmitter release, receptor activity, synaptic plasticity, learning, and memory. In the context of neuro-immune conditions, CaMKII serves as a functional marker that reflects how autoantibodies interact with neuronal cells.
This test measures the percentage increase in CaMKII activity when neuronal cells are exposed to a patient’s serum and compares it to a baseline reference. If autoantibodies in the blood bind to neuronal receptors or cell-surface molecules—such as dopamine receptors, tubulin, or lysogangliosides—they may stimulate or dysregulate CaMKII activity. Increased CaMKII activation suggests the immune system may be influencing intracellular signaling pathways that regulate mood, behavior, motor function, and cognition.
Elevated CaMKII activation has been observed in individuals with PANS (Pediatric Acute-Onset Neuropsychiatric Syndrome), PANDAS, Sydenham chorea, and other post-infectious or autoimmune neurological conditions. These conditions often follow infections such as strep, mycoplasma, or viral illnesses that can trigger an immune response affecting the brain.
CaMKII is a core component of the Autoimmune Brain Panel™, where it complements the four neuronal autoantibody titers (DRD1, DRD2L, anti-tubulin, anti-lysoganglioside GM1). While CaMKII elevation alone does not diagnose any disorder, it provides functional evidence that autoantibodies may be altering neuronal signaling. Interpreting CaMKII levels together with the other markers and clinical symptoms gives a clearer understanding of possible immune-mediated contributions to sudden-onset OCD, tics, anxiety, mood changes, movement abnormalities, regression, or behavioral shifts.
What does it mean if your CaM Kinase II (CaMKII), % of Baseline result is too high?
A high CaMKII activation level indicates increased stimulation of neuronal signaling pathways by the patient’s serum. This suggests immune-mediated effects on brain-cell receptors or cell-surface molecules. Elevated CaMKII activity may be associated with neuropsychiatric symptoms such as OCD behaviors, tics, emotional instability, impulsivity, anxiety, motor abnormalities, or cognitive changes.
This finding is most meaningful when combined with elevated neuronal autoantibodies in the Autoimmune Brain Panel™ and a clinical history consistent with neuro-immune activation.
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What does it mean if your CaM Kinase II (CaMKII), % of Baseline result is too low?
A low or normal CaMKII level indicates no significant activation of the CaMKII pathway by the patient’s serum. This suggests there is no current functional effect of autoantibodies on neuronal signaling through this mechanism.
However, neuro-immune issues may still be present through other pathways, so CaMKII should always be interpreted alongside the full panel and clinical symptoms.
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