b-Tetrahydrocortisone (b-THE) is an adrenal steroid and a cortisol metabolite. Tetrahydrocortison (THE) is a down-stream metabolite of cortisol and cortisone.
Cortisone is a pregnane steroid hormone closely related to cortisol. It is one of the main hormones released by the adrenal gland in response to stress. Cortisone suppresses the immune system, thus reducing inflammation and attendant pain and swelling at the site of the injury. Risks exist, in particular in the long-term use of cortisone. Cortisone, a glucocorticoid, and epinephrine (adrenaline) are the main substances released by the body as a reaction to stress. They elevate blood pressure and prepare the body for a fight or flight response. If there is excess cortisol to cortisone conversion or excess metabolization of cortisone, urinary levels of b-Tetrahydrocortisone (b-THE) will be high.
Vantyghem MC, Ghulam A, Hober C, Schoonberg C, D'Herbomez M, Racadot A, Boersma A, Lefebvre J. Urinary cortisol metabolites in the assessment of peripheral thyroid hormone action: overt and subclinical hypothyroidism. J Endocrinol Invest. 1998 Apr;21(4):219-25. doi: 10.1007/BF03347306. PMID: 9624595.
Excess cortisol will result in high levels of urinary bTetrahydrocortisone (b-THE).
Cortisone is a pregnane steroid hormone closely related to cortisol. It is one of the main hormones released by the adrenal gland in response to stress.
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