Microglia are a type of macrophage located throughout the brain and spinal cord that act as the first and main form of active immune defense in the CNS. These markers indicate a destruction of the blood brain barrier and are found to play a role in tissue destruction of Alzheimer’s disease.
References:
Zhang Z, Zoltewicz JS, Mondello S, Newsom KJ, Yang Z, Yang B, Kobeissy F, Guingab J, Glushakova O, Robicsek S, Heaton S, Buki A, Hannay J, Gold MS, Rubenstein R, Lu XC, Dave JR, Schmid K, Tortella F, Robertson CS, Wang KK. Human traumatic brain injury induces autoantibody response against glial fibrillary acidic protein and its breakdown products. PLoS One. 2014 Mar 25;9(3):e92698. doi: 10.1371/journal.pone.0092698. Erratum in: PLoS One. 2014;9(6):e101712. PMID: 24667434; PMCID: PMC3965455.
Anti-Microglia (IgM)
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