Anti-Lysoganglioside GM1, Titer
The Anti-Lysoganglioside GM1 test measures autoantibodies directed against lysoganglioside GM1, a glycolipid found in the membranes of neurons throughout the central and peripheral nervous system. These molecules play an important role in maintaining nerve structure, communication, and signal transmission. When the immune system produces antibodies that mistakenly target lysoganglioside GM1, it may interfere with normal neuronal function and contribute to immune-mediated neuroinflammation.
Elevated anti-GM1 titers have been observed in individuals experiencing sudden-onset or severe neuropsychiatric symptoms, including obsessive-compulsive behaviors, anxiety, tics, movement abnormalities, emotional dysregulation, and cognitive or behavioral regression. These antibodies are part of the immunological patterns described in PANS (Pediatric Acute-Onset Neuropsychiatric Syndrome), PANDAS, Sydenham chorea, and other post-infectious or autoimmune neurological conditions.
Because lysogangliosides are present on neuronal cell surfaces, antibodies against them may alter how neurons communicate, potentially affecting dopamine pathways and other neurotransmitter systems. This marker is one component of the Autoimmune Brain Panel™, a specialized test designed to identify neuro-immune activation affecting brain function.
On its own, an elevated anti-GM1 level does not diagnose any specific disorder, but it provides valuable supporting information when interpreted alongside other neuronal autoantibodies (DRD1, DRD2L, anti-tubulin), CaM Kinase II activation, symptom history, and recent infections such as strep or mycoplasma.
What does it mean if your Anti-Lysoganglioside GM1, Titer result is too high?
A high Anti-Lysoganglioside GM1 titer indicates the immune system is producing antibodies that may be targeting neuronal cell-surface molecules. Elevated levels can be associated with neuro-immune symptoms such as tics, OCD behaviors, mood swings, irritability, anxiety, or motor abnormalities.
A high result may reflect an active or recent immune trigger—often following infections like streptococcus, mycoplasma, or viral illnesses. Interpretation is most meaningful when reviewed alongside the full Autoimmune Brain Panel™ and clinical presentation.
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What does it mean if your Anti-Lysoganglioside GM1, Titer result is too low?
A low or normal Anti-Lysoganglioside GM1 titer indicates no significant autoantibody activity targeting lysoganglioside GM1. This suggests there is no current immune response against this neuronal structure. However, neuro-immune issues may still arise from other pathways, so results from the full panel—DRD1, DRD2L, anti-tubulin, and CaMKII—should also be considered.
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