The anti-Hu antibody is the most frequent manifestation of sensory neuropathy with frequent autonomic involvement. The clinical patterns of the neuropathies is in keeping with accordance with the cellular distribution of the HuD antigen.
→ Antibodies to Hu, Ri and Yo antigens are present in patients with paraneoplastic neurologic syndrome such as encephalomyelitis.
→ Hu antibodies are frequently associated with small cell lung cancer and neuroblastoma.
→ Hu antibodies are rarely associated with non-small cell lung cancer, prostate cancer or seminoma.
References:
Li J, Lin W. Various clinical features of patients with anti-Hu associated paraneoplastic neurological syndromes: An observational study. Medicine (Baltimore). 2018 May;97(18):e0649. doi: 10.1097/MD.0000000000010649. PMID: 29718880; PMCID: PMC6392975.
Anti-Hu (IgG + IgA)
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