ACCA

Optimal Result: 0 - 80 Units.

The IBD Expanded Panel test offers three novel markers:

- antichitobioside IgA (ACCA),

- antilaminaribioside IgG (ALCA),

- antimannobioside IgG (AMCA),

together with anti-Saccharomyces cerevisiae IgG (gASCA) and pANCA.

These markers provide additional diagnostic and prognostic information depending on the combination of results.

The antibodies included in the panel are:

- ASCA (anti-Saccharomyces cerevisiae antibodies),

- ALCA (antilaminaribioside carbohydrate antibodies),

- ACCA (antichitobioside carbohydrate antibodies),

AMCA (antimannobioside carbohydrate antibodies).

What does it mean if your ACCA result is too low?

How to interpret your results:

###Please look at all markers of this report together###

When the only positive marker is pANCA, the interpretive comment on the report will read: "Suggestive of ulcerative colitis."

When only one of ACCA, ALCA, AMCA, or gASCA is positive and pANCA is negative, the interpretive comment will read: "Suggestive of Crohn's disease. Pattern is not conclusive for disease behavior risk stratification."

When only one of ACCA, ALCA, AMCA, or gASCA is positive and pANCA is positive, the interpretive comment will read: "Suggestive of inflammatory bowel disease. Pattern is not conclusive for any specific disease form."

When any two of ACCA, ALCA, AMCA, or gASCA are positive and pANCA is positive or negative, the interpretive comment will read: "Suggestive of Crohn's disease with high risk of aggressive disease behavior (development of strictures or fistulae)."

When any three or more of ACCA, ALCA, AMCA, or gASCA are positive and pANCA is positive or negative, the interpretive comment will read: "Suggestive of Crohn's disease with the very high risk of aggressive disease behavior (development of strictures or fistulae)."

When all markers are negative, the interpretive comment on the report will read: "Pattern is not suggestive of inflammatory bowel disease."

What does it mean if your ACCA result is too high?

How to interpret your results:

###Please look at all markers of this report together###

When the only positive marker is pANCA, the interpretive comment on the report will read: "Suggestive of ulcerative colitis."

When only one of ACCA, ALCA, AMCA, or gASCA is positive and pANCA is negative, the interpretive comment will read: "Suggestive of Crohn's disease. Pattern is not conclusive for disease behavior risk stratification."

When only one of ACCA, ALCA, AMCA, or gASCA is positive and pANCA is positive, the interpretive comment will read: "Suggestive of inflammatory bowel disease. Pattern is not conclusive for any specific disease form."

When any two of ACCA, ALCA, AMCA, or gASCA are positive and pANCA is positive or negative, the interpretive comment will read: "Suggestive of Crohn's disease with high risk of aggressive disease behavior (development of strictures or fistulae)."

When any three or more of ACCA, ALCA, AMCA, or gASCA are positive and pANCA is positive or negative, the interpretive comment will read: "Suggestive of Crohn's disease with the very high risk of aggressive disease behavior (development of strictures or fistulae)."

When all markers are negative, the interpretive comment on the report will read: "Pattern is not suggestive of inflammatory bowel disease."

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Numerous studies of CD have demonstrated an association between ileal disease (ileal = last part of the small intestine) and the presence of ACCA, ALCA, AMCA, and ASCA. Among these antibodies, the association with localization to the small intestine increased with the number of positive antibodies and with the concentration of individual antibodies. A more aggressive or complicated disease course in CD (as indicated by stricturing or perforation of the intestine or need for surgery), has also been associated with the presence of ACCA, ALCA, AMCA, and ASCA. Among these antibodies, the association with complicated disease behavior or surgery increased with the number and concentration of antibodies.

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