3-Methylhippurate

Urine
Optimal Result: 0 - 0.18 ug/mg creatinine.

3-Methylhippurate is a Xylene Metabolite.

Xylene is found in many solvents (paints, perfumes, etc.). Used in insecticide\pesticide application. Metabolized to Methylhippurate, which is measured in urine. 

Sources of exposure:

Mainly by inhalation of vapors. Natural component of petroleum and coal tar. Motor and aviation fuel additive. Automotive emissions, poor emission-control devices on older vehicles, poor maintenance practices, aviation fuel, waste and landfill sites, localized industrial discharges and spillage incidents, tobacco smoke.

Topical contact or inhalation of:

varnish/polishers, paint, paint thinner, paint remover, shellac, rust preventatives, lacquers, inks, dyes, adhesives, cleaning fluids, degreasing agents, household cleaning products.

Used as a solvent for rubbers, synthetic resins, gums, inks, paint. Fabric and leather treatments. Used in the synthesis of plasticizers and in the manufacture of polyester fiber, film, insecticide formulations, and perfumes.

Occupational Exposure:

paint and printing ink industries, automobile body and related repairers, photographic processing, rubber, leather, plastics and textile industries, flooring contractor.

Effects:

Depression of the central nervous system. Neuropsychological and neurophysiological dysfunction. Anemia, thrombocytopaenia, renal damage. Irritation of mucous membranes, dermatitis, nausea, fatigue, headache, anxiety. Dyspnea, cyanosis.

Metabolism:

Xylene is metabolized in the liver by cytochrome P-450-dependent multifunction oxidase enzymes, conjugated principally with glycine and excreted in the urine as methylhippuric acids. Conjugation with sulfate or glucuronic acid represents a minor pathway.

Urinary levels of 2, and 3-methylhippurate provide a valid complement to ambient monitoring.

Although the 2-isomer exhibits a longer half-life, the 3-isomer is the principle component making up 45-70% of co Trimethylbenzene Metabolite (3,4-Dimethylhippurate).

What does it mean if your 3-Methylhippurate result is too high?

Sources of exposure:

- Mainly by inhalation of vapors.

- Natural component of petroleum and coal tar.

- Motor and aviation fuel additive.

- Automotive emissions, poor emission-control devices on older vehicles, poor maintenance practices, aviation fuel, waste and landfill sites, localized industrial discharges and spillage incidents, tobacco smoke.

- Topical contact or inhalation of: varnish/polishers, paint thinner, paint remover, shellac, rust preventatives, lacquers, inks, dyes, adhesives, cleaning fluids, degreasing agents, household cleaning products.

- Used as a solvent for rubbers, synthetic resins, gums, inks, paint.

- Fabric and leather treatments.

- Used in the synthesis of plasticizers and in the manufacture of polyester fiber, film, insecticide formulations and perfumes.

Occupational Exposure: paint and printing ink industries, automobile body and related repairer, photographic processing, rubber, leather, plastics, and textile industries, flooring contractor.

Effects:

- Depression of the central nervous system.

- Neuropsychological and neurophysiological dysfunction.

- Anemia, thrombocytopaenia, renal damage.

- Irritation of mucous membranes, dermatitis, nausea, fatigue, heachache, anxiety.

- Dyspnea, cyanosis.

Metabolism:

- Xylene is metabolized in the liver by cytochrome P-450-dependent multifunction oxidase enzymes, conjugated principally with glycine and excreted in the urine as methylhippuric acids. Conjugation with sulfate or glucuronic acid represents a minor pathway.

- Urinary levels of 2, and 3-methylhippurate provide a valid complement to ambient monitoring. Although the 2-isomer exhibits a longer half-life, the 3-isomer is the principle component making up 45-70% of commerical xylene.

- Xylene does not accumulate significantly in body tissues.

10 000+ happy customers
100% satisfaction
★ ★ ★ ★ ★ customer support

Trust us to examine your lab results, guiding you towards improved health.

Use promo code to save 10% off any plan.


We implement proven measures to keep your data safe.

At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.