11-Dehydrotetrahydrocorticosterone (THA)

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What is 11-Dehydrotetrahydrocorticosterone (THA)?

11-Dehydrotetrahydrocorticosterone (THA) is a metabolite of tetrahydrocorticosterone (THB), which itself comes from corticosterone, an adrenal corticosteroid hormone. Corticosterone is produced by the adrenal cortex and helps regulate the body’s stress response, immune activity, energy metabolism, and electrolyte balance.

THA represents a downstream product in the adrenal steroid pathway and reflects how efficiently the body is converting and clearing corticosterone through enzyme systems such as 11b-hydroxysteroid dehydrogenase (11b-HSD). Measuring THA in urine offers valuable insight into adrenal function, stress hormone metabolism, and liver detoxification capacity.


Why is THA important?

The balance between THA and its related metabolites (THB and corticosterone) helps show how active or sluggish your adrenal hormone metabolism is.

  • When adrenal function is strong, corticosterone is produced and metabolized efficiently into THB and THA.

  • When adrenal output is weak, both THB and THA may be reduced, indicating low corticosteroid turnover.

  • When stress is chronic or excessive, THA may rise as the body increases corticosteroid metabolism to keep up with demand.

Tracking THA helps identify subtle imbalances in how your adrenal system is responding to stress and maintaining homeostasis.


Key takeaway

11-Dehydrotetrahydrocorticosterone (THA) provides a window into how your body metabolizes corticosterone, an essential adrenal stress hormone.

  • Elevated THA suggests increased adrenal activity or accelerated steroid metabolism.

  • Low THA indicates reduced adrenal output or slowed corticosteroid processing.

Interpreting THA alongside related metabolites—such as THB, corticosterone, cortisone (E), and tetrahydrocortisol (THF)—helps build a comprehensive picture of adrenal function, stress adaptation, and hormonal resilience.

What does it mean if your 11-Dehydrotetrahydrocorticosterone (THA) result is too high?

High THA levels suggest increased corticosterone metabolism and can be a sign that your adrenal glands are working harder than usual or that cortisol-like compounds are being broken down rapidly.

Possible causes:

  • Chronic or acute stress (physical or emotional)

  • High adrenal output or hypercortisolism

  • Inflammation or immune activation

  • Overtraining or excessive physical activity

  • Use of corticosteroid medications

  • Increased 11β-HSD2 enzyme activity (which converts active corticosteroids into inactive forms)

Possible symptoms:

  • Feeling “wired but tired”

  • Sleep disturbances or early waking

  • Anxiety or restlessness

  • Elevated blood pressure

  • Sugar cravings or midsection weight gain

Supportive measures:

  • Prioritize rest and recovery between stressful events

  • Manage caffeine and stimulant use

  • Focus on balanced nutrition with anti-inflammatory foods

  • Consider adaptogenic herbs (ashwagandha, rhodiola) under professional guidance

  • Address chronic inflammation or overtraining if applicable

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What does it mean if your 11-Dehydrotetrahydrocorticosterone (THA) result is too low?

Low THA levels may reflect reduced adrenal activity or slowed metabolism of corticosterone, often seen in individuals experiencing chronic stress depletion or adrenal fatigue.

Possible causes:

  • Adrenal exhaustion or insufficiency

  • Reduced corticosterone production

  • Impaired 11β-HSD enzyme function

  • Pituitary dysfunction (low ACTH)

  • Chronic illness or infection

  • Nutrient deficiencies (vitamin C, B5, magnesium)

  • Long-term corticosteroid use suppressing adrenal output

Possible symptoms:

  • Persistent fatigue and low motivation

  • Brain fog or poor concentration

  • Low blood pressure or dizziness

  • Low stress tolerance

  • Mood changes or depressive symptoms

  • Cravings for salt or stimulants

Supportive measures:

  • Ensure consistent sleep and recovery

  • Support adrenal repair with vitamin C, B5, magnesium, and electrolytes

  • Maintain steady blood sugar with regular, balanced meals

  • Limit alcohol, caffeine, and overexertion

  • Discuss results with a healthcare provider to assess adrenal and pituitary function

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