Zonulin is a marker of intestinal permeability, otherwise known as leaky gut. If a person has elevated Zonulin levels, the normal regulation of the tight junctions is compromised.
Zonulin is a protein that is synthesized in intestinal cells and liver cells. It is a key biomarker for intestinal permeability and is the only regulator of intestinal permeability that is reversible.
What is intestinal permeability?
Intestinal permeability, often referred to as "leaky gut," is a condition where the lining of the small intestine becomes damaged, causing undigested food particles, toxins, and bacteria to leak through the intestinal wall into the bloodstream. Normally, the gut lining acts as a barrier, selectively allowing nutrients to pass through while keeping harmful substances out. When this barrier is compromised, it can lead to inflammation and trigger immune responses, potentially contributing to various health issues such as food sensitivities, digestive problems, and even autoimmune diseases.
It is estimated that anywhere between 50 and 100 percent of food intolerance sufferers have increased intestinal permeability.
What can cause increased intestinal permeability?
Increased intestinal permeability can be caused by food allergies and sensitivities, stress, infections, and low stomach acid, among other causes.
What are elevated Zonulin levels associated with?
Elevated levels of Zonulin are associated with Celiac Disease, Autoimmune disease, and Multiple Sclerosis, in addition to other chronic illnesses.
Healthy versus leaky gut:
In a healthy gut, there are healthy cell junctions and good nutrient absorption. In a leaky gut, however, the Villi are damaged, there is poor absorption and the cell junctions are loose. This means that bacteria and unwanted items can pass through the gut.
Zonulin IgA1-2
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