Tetrahydrocorticosterone (THB) is a metabolite of corticosterone, an adrenal corticosteroid involved in the stress response and regulation of metabolism, immune function, and electrolyte balance. THB reflects downstream metabolism in the adrenal steroid pathway and provides insights into overall adrenal function.
Elevated levels of THB may indicate increased adrenal activity, often associated with chronic stress, HPA axis dysregulation, or conditions causing excessive production of corticosteroids, such as Cushing's syndrome. Conversely, low levels may suggest adrenal insufficiency, reduced steroid production, or impaired metabolism of corticosterone.
Assessing THB levels can help healthcare providers evaluate adrenal health, detect imbalances in corticosteroid metabolism, and guide interventions to optimize adrenal and hormonal function.
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Elevated levels of Tetrahydrocorticosterone (THB) indicate increased adrenal corticosteroid activity and may be associated with several conditions, including:
Chronic Stress: Prolonged activation of the hypothalamic-pituitary-adrenal (HPA) axis increases corticosterone production, leading to elevated THB as a downstream metabolite.
HPA Axis Dysregulation: Disorders like Cushing's syndrome or functional adrenal hyperactivity can result in excessive corticosteroid production and elevated THB levels.
Inflammation or Immune Response: Corticosteroids play a key role in managing inflammation, and elevated THB may reflect the body's response to chronic or acute inflammatory conditions.
Corticosteroid Supplementation: Use of exogenous corticosteroids or excessive supplementation may increase THB levels as part of elevated steroid metabolism.
High THB levels serve as a marker of increased adrenal activity and may indicate an underlying stress-related, metabolic, or endocrine imbalance, warranting further investigation and tailored management strategies.
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Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
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11-Dehydrotetrahydrocorticosterone (THA), 11b-Hydroxyandrosterone, 11b-Hydroxyetiocholanolone, 16a-OH Estrone (16aOHE1), 1st Morning Cortisol, 1st Morning Cortisone, 1st Morning Creatinine, 2-Methoxyestradiol, 2-Methoxyestrone, 2-OH Estrone (2OHE1), 2/16 Ratio, 2nd Morning Cortisol, 2nd Morning Cortisone, 2nd Morning Creatinine, 4-OH Estrone (4OHE1), 5a-Androstanediol, 5a-THF/THF Ratio, 5b-Androstanediol, 5b-Pregnanediol, 6-Sulfatoxymelatonin (1st Morning), Adrenal Reserve (THE+5a-THF+THF), Afternoon Cortisol, Afternoon Cortisone, Afternoon Creatinine, Allo-Tetrahydrocorticosterone (5a-THB), Allo-Tetrahydrocortisol (5a-THF), Andro/Etio Ratio, Androsterone, Cortisol (F), Cortisol/Cortisone Ratio (11b-HSD II), Cortisone (E), DHEA, DHT, Estradiol (E2), Estriol (E3), Estrogen Quotient, Estrone (E1), Etiocholanolone, Free T3, Free T4, Kynurenic, Methylation Ratio, Na/K Ratio, Night Cortisol, Night Cortisone, Night Creatinine, Potassium, Pregnanetriol, Sodium, Testosterone, Tetrahydrocorticosterone (THB), Tetrahydrocortisol (THF), Tetrahydrocortisone (THE), Total (E1 + E2 + E3), Xanthurenic
