Antigen Made From:
Packaged Sorghum flour
Associated With:
- Allergy
- Asthma
Known Cross-Reactions: Corn/Maize, Millet, Neurospora crassa (a bread mold), Triiodothyronine (T3)
Clinical Significance:
The presence of antibodies to Sorghum is an indication of food immune reactivity. The offending food and its known cross-reactive foods should be eliminated from the diet. Sorghum flour, although difficult to process, is becoming a popular alternative flour to use in gluten-free baking. A study on the effects of Sorghum in celiac patients showed that the flour was not antigenic. If a recently diagnosed gluten-reactive patient results with high levels of antibodies against Sorghum, it is most likely due to the late introduction of the food to the patient’s diet, rather than a gluten-associated reaction.
References:
1. Pawar. Sensitivity to Sorghum vulgare (jowar) pollens in allergic bronchial asthma and effect of allergen specific immunotherapy.
Indian J Allergy Asthma Immunol, 2002; 16(1):41-45.
2. Bietz. Cereal prolamin evolution and homology revealed by sequence analysis. Biochm Gentics, 1982; 20(11/12):1039-1053.
3. Cicek and Esen. Structure and expression of a dhurrinase (b-glucosidase) from sorghum. Plant Physiol, 1998; 116:1469-1478.
4. Parameswaran and Thayumanavan. Isolation and characterization of a 20 kD prolamin from kodo millet (Paspalum scrobiculatum)
(L.): homology with other millets and cereals. Plant Foods Human Nutr, 1997; 50:359-373.
5. Virdi et al. A sorghum 85 kDa heat stress-modulated protein shows calmodulin-binding properties and cross-reactivity to antiNeurospora crassa Hsp 80 antibodies. FEBS Letters, 2009; 583:767-770.
6. Kharrazian, et al. Immunological reactivity using monoclonal and polyclonal antibodies of autoimmune thyroid target sites with
dietary proteins. J Thyroid Res, 2017; 2017:4354723.
7. Ciacci et al. Celiac disease: in vitro and in vivo safety and palatability of wheat-free sorghum food products. Clin Nutr,
2007; 26(6):799-805.
Sorghum
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