Pyroglutamate (Male)
Optimal Result:
38 - 83 ug/mg.
Pyroglutamate is an intermediate in glutathione recycling and production. Glutathione requires the amino acids cysteine, glycine and glutamate for production. If the body cannot convert pyroglutamate forward to glutathione, it will show up elevated in the urine. High pyroglutamate is an established marker for glutathione deficiency. Remember that glutathione is one of the most potent antioxidants in the human body and is especially important in getting rid of toxins including the reactive quinone species formed by 4-OH-E1 and 4-OH-E2. This reactive species can damage DNA if not detoxified by either methylation or glutathione.
Some have reported that low pyroglutamate may also be indicative of a need for glutathione; however, this is not established in the scientific literature.
Note: Pyroglutamate in the urine can also be elevated with Italian cheese consumption. Italian Cheeses (parmesan, etc.) may transiently increase pyroglutamate because they use a thermophilic lactobacilli to ripen the cheese- which our gut breaks down into pyroglutamate. This is not clinically significant and only reflects that they ate this style of cheese (if applicable).
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What does it mean if your Pyroglutamate (Male) result is too high?
Pyroglutamate is an intermediate in glutathione recycling and production. Glutathione requires the amino acids cysteine, glycine and glutamate for production. If the body cannot convert pyroglutamate forward to glutathione, it will show up elevated in the urine. High pyroglutamate is an established marker for glutathione deficiency. Remember that glutathione is one of the most potent antioxidants in the human body and is especially important in getting rid of toxins including the reactive quinone species formed by 4-OH-E1 and 4-OH-E2. This reactive species can damage DNA if not detoxified by either methylation or glutathione.
Note: Pyroglutamate in the urine can also be elevated with Italian cheese consumption. Italian Cheeses (parmesan, etc.) may transiently increase pyroglutamate because they use a thermophilic lactobacilli to ripen the cheese- which our gut breaks down into pyroglutamate. This is not clinically significant and only reflects that they ate this style of cheese (if applicable).
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What does it mean if your Pyroglutamate (Male) result is too low?
Some have reported that low pyroglutamate may also be indicative of a need for glutathione; however, this is not established in the scientific literature.
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