Platinum (Pt) is a nonessential element that is sometimes detected in feces. However, the clinical significance of high levels of Pt in feces has not been well studied. Platinum is poorly absorbed in the gut and high level of oral exposure is unusual. Since it is a relatively rare element, most Pt exposures are of occupational origin. There may have been a slight increase in environmental Pt due to the use of Pt in automobile catalytic converters. Pt is a byproduct of copper refining and used as an alloy in some dental and orthopedic materials.
High urinary Pt post-chelation has been reported for patients who had received platinum-based chemotherapy, and individuals who had been making high quality jewelry for years. The platinum-based drugs cisplatin, carboplatin and oxaliplatin are commonly used intravenously in the treatment of cancer and while they are effective, their use is limited by their severe, dose-limiting side effects. The extent to which different platinum-based drugs and their metabolites are excreted in bile after infusion has not been well characterized, but Pt has a very long life-time in the body. The liver is a prominent site of retention.
Hair elements analysis may reveal exposure to Pt over the past 2-4 months.
Platinum
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