Pap Smear

Sample type: Cervical cells
Negative (NIL)

A negative (NIL) result on a Pap smear means "Negative for Intraepithelial Lesion or Malignancy" — indicating that no abnormal, precancerous, or cancerous cells were found in the cervical sample. This is a normal result and suggests that the cervix appears healthy at the time of the test.

If your Pap smear result is negative (NIL) but your HPV test (e.g., Aptima) is positive, it means:

  • No abnormal cervical cells were found at the time of the test (Pap = normal).

  • However, you do have a high-risk strain of HPV, which can increase your risk of developing abnormal cells in the future.

What Is a Pap Smear?

A Pap smear, also called a Pap test, is a simple and important screening procedure used to detect abnormal cells in the cervix — the lower part of the uterus that opens into the vagina. It helps identify changes that may lead to cervical cancer, often before any symptoms appear.

During the test, a healthcare provider gently collects a small sample of cells from the cervix using a soft brush or swab. These cells are then examined under a microscope or analyzed in a lab to check for precancerous changes, infections, or other abnormalities.


Why It's Done

The Pap smear is a key part of routine gynecological care. It can detect early signs of cervical cancer and conditions like HPV-related cell changes, allowing for early treatment and better outcomes.

Most women and individuals with a cervix should begin screening around age 21 and continue at regular intervals, as recommended by their healthcare provider.


What the Results Mean

  • Normal (Negative): No abnormal cells were found.

  • Abnormal (Positive): Some cells look unusual and may require further testing, such as another Pap smear, an HPV test (a test that detects the presence of high-risk human papillomavirus DNA or RNA in cervical cells to help identify the risk of developing cervical cancer), or a colposcopy (a procedure that allows a doctor to closely examine the cervix using a special magnifying instrument called a colposcope).


Combined with HPV Testing

Pap smears are often done alongside HPV testing, which looks for high-risk strains of human papillomavirus — the main cause of cervical cancer.


Quick Facts

  • Test Type: Cervical cell screening

  • Specimen: Cervical swab (collected during pelvic exam)

  • Purpose: Detects abnormal or precancerous cervical cells

  • Recommended for: Individuals with a cervix, typically ages 21–65

Pap Smear
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